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GlossaryExtracellular Signal-Regulated Kinase (MAPK)

protein that transmits signals from cell surface to DNA

Extracellular Signal-Regulated Kinase (ERK) is a type of protein kinase that plays a crucial role in the MAPK (Mitogen-Activated Protein Kinase) signaling pathway. It helps transmit signals from the cell surface to the DNA in the cell nucleus, influencing processes like cell division, differentiation, and survival. This pathway is important in various biological functions and can be implicated in conditions like cancer and alopecia when dysregulated.

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research LL-37 Stimulates the Functions of Adipose-Derived Stromal/Stem Cells via Early Growth Response 1 and the MAPK Pathway

53 citations, April 2016 in “Stem cell research & therapy”

LL-37 helps stem cells grow and move, aiding tissue regeneration and hair growth.

research Gab1 and MAPK Signaling Are Essential in the Hair Cycle and Hair Follicle Stem Cell Quiescence

36 citations, October 2015 in “Cell reports”

Gab1 protein is crucial for hair growth and stem cell renewal, and Mapk signaling helps maintain these processes.

research Quercitrin Stimulates Hair Growth with Enhanced Expression of Growth Factors via Activation of MAPK/CREB Signaling Pathway

25 citations, September 2020 in “Molecules”

Quercitrin may help treat hair loss by promoting hair growth and improving cell health.

research Involvement of Activation of Mitogen-Activated Protein Kinase (MAPK)/Extracellular Signal-Regulated Kinase (ERK) Signaling Pathway in Proliferation of Urethral Plate Fibroblasts in Finasteride-Induced Rat Hypospadias

10 citations, December 2018 in “Medical Science Monitor”

The MAPK/ERK pathway is crucial in controlling cell growth and death in finasteride-induced hypospadias.

research Reductive Stress Selectively Disrupts Collagen Homeostasis and Modifies Growth Factor-independent Signaling Through the MAPK/Akt Pathway in Human Dermal Fibroblasts

9 citations, March 2019 in “Molecular & cellular proteomics”

Reductive stress messes up collagen balance and alters cell signaling in human skin cells, which could help treat certain skin diseases.

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community New Research- Creatine Increasing Scalp DHT Without Corresponding Serum DHT Increase

in Research/Science 122 upvotes 6 months ago

Creatine may increase scalp DHT without affecting serum DHT, potentially speeding up male pattern baldness (MPB) for those genetically prone. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community Polydopamine Synergizes with Quercetin Nanosystem to Reshape the Perifollicular Microenvironment for Accelerating Hair Regrowth in Androgenetic Alopecia.

in Research/Science 13 upvotes 6 months ago

A quercetin-encapsulated and polydopamine-integrated nanosystem (PDA@QLipo) shows promise for treating androgenetic alopecia by reshaping the perifollicular microenvironment, outperforming minoxidil in hair regeneration. The nanosystem promotes cell proliferation, hair follicle renewal, and recovery by scavenging reactive oxygen species and enhancing neovascularity.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 44 upvotes 4 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.