Genome-Wide Maps of Histone Modifications Unwind In Vivo Chromatin States of the Hair Follicle Lineage

September 2011 in “ Cell stem cell ”

Wen-Hui Lien, Xingyi Guo, Lisa Polak, Lee N. Lawton, Richard A. Young, Deyou Zheng, Elaine Fuchs

hair follicle stem cells chromatin polycomb-group H3K27-trimethylation HF-SCs transit-amplifying progeny H3K27me3 stemness quiescence activation repression differentiation TA progeny

TLDR Hair follicle stem cells use specific chromatin changes to control their growth and differentiation.

The study investigated how hair follicle stem cells (HF-SCs) in mouse skin remodel chromatin in response to activation cues, focusing on the role of polycomb-group (PcG)-mediated H3K27-trimethylation. It was found that PcG represses nonskin lineages and HF differentiation in HF-SCs, while in their transit-amplifying (TA) progeny, nonskin regulators remain repressed, HF-SC regulators gain H3K27me3 marks, and HF-lineage regulators lose them. This chromatin mapping revealed how HF-SCs maintain their stemness through cycles of quiescence and activation, highlighting the importance of PcG-mediated repression in the irreversible fate switch of these cells.

View this study on cell.com →

Discuss this study in the Community →

Research cited in this study

8 / 8 results

research Conditional Activin Receptor Type 1B (Acvr1b) Knockout Mice Reveal Hair Loss Abnormality

46 citations, December 2010 in “The journal of investigative dermatology/Journal of investigative dermatology”

Disrupting Acvr1b in mice causes severe hair loss and thicker skin.

research Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin

1039 citations, February 2009 in “Nature Reviews Molecular Cell Biology”

Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.

research Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells

835 citations, October 2008 in “Nature Genetics”

Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.

research Scratching the Surface of Skin Development

788 citations, February 2007 in “Nature”

The document concludes that skin stem cells are important for hair growth and wound healing, and could be used in regenerative medicine.

research Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells

550 citations, December 2005 in “The Journal of clinical investigation/The journal of clinical investigation”

Researchers successfully isolated and identified key markers of stem cell-enriched human hair follicle bulge cells.

research Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle

417 citations, September 2005 in “PLoS biology”

Understanding gene expression in hair follicles can reveal insights into hair growth and disorders.

research Defining the Impact of Beta-Catenin/Tcf Transactivation on Epithelial Stem Cells

384 citations, June 2005 in “Genes & development”

β-catenin is essential for stem cell activation and proliferation in hair follicles.

research Control of Pelage Hair Follicle Development and Cycling by Complex Interactions Between Follistatin and Activin

81 citations, January 2003 in “The FASEB Journal”

Follistatin helps hair growth and cycling, while activin prevents it.

Similar Research

5 / 1000+ results

research Epigenetic Regulation in Adult Stem Cells and Cancers

20 citations, January 2013 in “Cell & Bioscience”

Understanding how epigenetic regulation affects stem cells is key to cancer insights and new treatments.

research Polycomb Repressive Complex 2 in Adult Hair Follicle Stem Cells Is Dispensable for Hair Regeneration

6 citations, December 2021 in “PLoS Genetics”

Polycomb Repressive Complex 2 is not needed for hair regeneration.

research EZH2-Mediated Inhibition of MicroRNA-22 Promotes Differentiation of Hair Follicle Stem Cells by Elevating STK40 Expression

12 citations, July 2020 in “Aging”

The protein EZH2 blocks microRNA-22, increasing STK40 protein, which helps hair follicle stem cells change and grow hair.

research Deciphering Principles of Morphogenesis from Temporal and Spatial Patterns on the Integument

19 citations, April 2015 in “Developmental Dynamics”

The conclusion is that skin and hair patterns are formed by a mix of cell activities, molecular signals, and environmental factors.

research Hoxc-Dependent Mesenchymal Niche Heterogeneity Drives Regional Hair Follicle Regeneration

43 citations, August 2018 in “Cell Stem Cell”

Hoxc genes control hair growth through Wnt signaling.

Genome-Wide Maps of Histone Modifications Unwind In Vivo Chromatin States of the Hair Follicle Lineage

Research cited in this study

research Conditional Activin Receptor Type 1B (Acvr1b) Knockout Mice Reveal Hair Loss Abnormality

research Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin

research Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells

research Scratching the Surface of Skin Development

research Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells

research Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle

research Defining the Impact of Beta-Catenin/Tcf Transactivation on Epithelial Stem Cells

research Control of Pelage Hair Follicle Development and Cycling by Complex Interactions Between Follistatin and Activin

Related Community Posts Join

community TWIST-1 and the cure: Is it really that easy?

community redensyl - follicle stem cell activator any experiences?

community Best Microneedle Lengths To Stimulate Stem Cells

community PP405: The Ultimate Hair Loss Drug for Complete Hair Growth

community TDM-105795 phase 2 results are in!