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research Genome-wide Maps of Histone Modifications Unwind In Vivo Chromatin States of the Hair Follicle Lineage

191 citations , September 2011 in “Cell stem cell”

This study found that polycomb-group-mediated repression plays a key role in regulating hair follicle stem cell states and lineage progression by distinct mechanisms in adult mouse skin.

research 560 Isolation of an “early” transit amplifying keratinocyte population in interfollicular human epidermis: a role for CD271 receptor

November 2022 in “Journal of Investigative Dermatology”

This study found that "early" transit amplifying cells, marked by CD271, are the first keratinocyte stem cell progenitors with distinct features, playing a significant role in early epidermal differentiation and regeneration.

research Defining the impact of β-catenin/Tcf transactivation on epithelial stem cells

384 citations , June 2005 in “Genes & development”

This study found that stabilized beta-catenin is crucial for activating stem cell transition from quiescence to proliferation in hair follicles by influencing gene expression within the stem cell niche.

research Abstract 5219: The role of MEK and Antizyme in keratinocyte stem cell expansion and differentiation

1 citations , April 2012 in “Cancer Research”

This study found that overexpression of antizyme in MEK-activated transgenic mice reduced skin tumor development and restored normal differentiation of keratinocyte progenitor cells, highlighting the role of polyamines in keratinocyte biology.

research Progenitor Cell Dysfunctions Underlie Some Diabetic Complications

46 citations , June 2015 in “American Journal Of Pathology”

This review highlights how diabetes affects stem and progenitor cells through altered signaling and homeostasis, impacting tissue function and complicating diabetic therapy efforts; new clinical results are not presented.

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community M25: Getting way too many DMs, so let’s do this here! AMA about Male Pattern Baldness, Hair Loss, and Products (100% Science-Backed )

1951 upvotes 5 months ago

Finasteride, dutasteride, and minoxidil are discussed as treatments for male pattern baldness. Finasteride and dutasteride are effective DHT blockers, while minoxidil is necessary for regrowth but must be used consistently.

community Don’t like the density at all, 2nd hair transplant

in Transplants 160 upvotes 8 months ago

The user is unhappy with the results of their second hair transplant, feeling that grafts were wasted on an already transplanted hairline instead of increasing mid-scalp density. They regret stopping medications like Dutasteride, Minoxidil, and RU58841, which led to significant hair loss, and plan to restart them.

community Don’t Get Too Hyped About PP405. We've Seen This Movie Before.

218 upvotes 1 year ago

PP405 is a new hair loss treatment showing early promise with a 20% hair density increase, but skepticism exists due to past failures of similar treatments like Pyrilutamide, RU58841, and Bimatoprost. Users debate its potential effectiveness, with some hopeful due to Google's involvement, while others urge caution without more evidence.

community Can't believe I've slept on microneedling for so long.

in Microneedling 584 upvotes 1 year ago

Microneedling with minoxidil and finasteride greatly improves hair regrowth. Using 0.5mm depth every other day boosts minoxidil absorption without side effects.

community Don't just focus on Finasteride, Minoxidil and Ketaconozole/Derma rolling

18 upvotes 4 years ago

Improving hair health involves not only using treatments like finasteride, minoxidil, and ketoconazole but also focusing on a healthy lifestyle, including diet, exercise, and stress management. A balanced approach enhances treatment effectiveness and overall well-being.

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