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    Glossary H3K27me3

    chemical modification on histone H3 that represses gene expression

    H3K27me3 stands for trimethylation of the 27th lysine residue on histone H3, a protein around which DNA is wrapped. This specific chemical modification is associated with the repression of gene expression, meaning it can turn off certain genes. In the context of hair and alopecia, changes in H3K27me3 levels can influence the activity of genes involved in hair growth and loss.

    Research 10 of 100

    1. EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair Genes & Development · 2011 · 354 citations
    2. Genome-wide Maps of Histone Modifications Unwind In Vivo Chromatin States of the Hair Follicle Lineage Cell stem cell · 2011 · 191 citations
    3. Telomere dysfunction impairs epidermal stem cell specification and differentiation by disrupting BMP/pSmad/P63 signaling PLOS genetics · 2019 · 19 citations
    4. Lineage commitment of dermal fibroblast progenitors is controlled by Kdm6b‐mediated chromatin demethylation The EMBO Journal · 2023 · 10 citations
    5. Polycomb repressive complex 2 in adult hair follicle stem cells is dispensable for hair regeneration PLoS Genetics · 2021 · 6 citations
    6. Lineage Commitment of Dermal Fibroblast Progenitors is Mediated by Chromatin De-repression bioRxiv (Cold Spring Harbor Laboratory) · 2023 · 1 citations
    7. The Role of Histone Demethylases in Disease Springer eBooks · 2011 · 1 citations
    8. Epigenetic and transcriptional profiling of secondary hair follicle stem cells during cashmere growth Scientific Data · 2026
    9. 864 Catalytic-dependent and -independent activities of Polycomb repressive complex 1 differentially regulate skin stem cell specification Journal of Investigative Dermatology · 2017
    10. Understanding The Molecular Mechanisms Of Hair Follicle Stem Cell Quiescence And Genome Plasticity eCommons (Cornell University) · 2013
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