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    Glossary H3K27me3

    chemical modification on histone H3 that represses gene expression

    H3K27me3 stands for trimethylation of the 27th lysine residue on histone H3, a protein around which DNA is wrapped. This specific chemical modification is associated with the repression of gene expression, meaning it can turn off certain genes. In the context of hair and alopecia, changes in H3K27me3 levels can influence the activity of genes involved in hair growth and loss.

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    1. EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair Genes & Development · 2011 · 354 citations
    2. Genome-wide Maps of Histone Modifications Unwind In Vivo Chromatin States of the Hair Follicle Lineage Cell stem cell · 2011 · 191 citations
    3. Telomere dysfunction impairs epidermal stem cell specification and differentiation by disrupting BMP/pSmad/P63 signaling PLOS genetics · 2019 · 19 citations
    4. Lineage commitment of dermal fibroblast progenitors is controlled by Kdm6b‐mediated chromatin demethylation The EMBO Journal · 2023 · 10 citations
    5. Polycomb repressive complex 2 in adult hair follicle stem cells is dispensable for hair regeneration PLoS Genetics · 2021 · 6 citations
    6. Lineage Commitment of Dermal Fibroblast Progenitors is Mediated by Chromatin De-repression bioRxiv (Cold Spring Harbor Laboratory) · 2023 · 1 citations
    7. The Role of Histone Demethylases in Disease Springer eBooks · 2011 · 1 citations
    8. Epigenetic and transcriptional profiling of secondary hair follicle stem cells during cashmere growth Scientific Data · 2026
    9. 864 Catalytic-dependent and -independent activities of Polycomb repressive complex 1 differentially regulate skin stem cell specification Journal of Investigative Dermatology · 2017
    10. Understanding The Molecular Mechanisms Of Hair Follicle Stem Cell Quiescence And Genome Plasticity eCommons (Cornell University) · 2013
    11. Scoring systems for pemphigus Dermatologica Sinica · 2023
    12. Hypoxia in Cell Reprogramming and the Epigenetic Regulations Frontiers in Cell and Developmental Biology · 2021 · 36 citations
    13. Integration of Biochemical and Mechanical Signals at the Nuclear Periphery: Impacts on Skin Development and Disease Stem cell biology and regenerative medicine · 2018
    14. 252 Follicle dermal papilla cells undergo chromatin remodelling processes in vivo and in vitro Journal of Investigative Dermatology · 2017
    15. 250 Sweat glands shrink upward with aging, causing dermal layer defects that lead to loss of skin elasticity and wrinkling-establishment of 3D imaging method for skin appendages Journal of Investigative Dermatology · 2017
    16. 254 WITHDRAWN Journal of Investigative Dermatology · 2017
    17. ATP-dependent chromatin remodeling during mammalian development Development · 2016 · 182 citations
    18. Epigenetic control of adult stem cell function Nature Reviews Molecular Cell Biology · 2016 · 179 citations
    19. The Harmonies Played by TGF-β in Stem Cell Biology Cell Stem Cell · 2012 · 156 citations
    20. A matter of life and death: self‐renewal in stem cells EMBO Reports · 2012 · 150 citations
    21. Epithelial Skin Biology Current Topics in Developmental Biology · 2016 · 118 citations
    22. Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells Cell · 2020 · 77 citations
    23. JunB defines functional and structural integrity of the epidermo-pilosebaceous unit in the skin Nature Communications · 2018 · 48 citations
    24. Hoxc-Dependent Mesenchymal Niche Heterogeneity Drives Regional Hair Follicle Regeneration Cell Stem Cell · 2018 · 43 citations
    25. Epigenetic control of skin and hair regeneration after wounding Experimental Dermatology · 2014 · 36 citations
    26. Cellular senescence in tissue repair: every cloud has a silver lining The International Journal of Developmental Biology · 2018 · 33 citations
    27. An Intrinsic Oscillation of Gene Networks Inside Hair Follicle Stem Cells: An Additional Layer That Can Modulate Hair Stem Cell Activities Frontiers in Cell and Developmental Biology · 2020 · 23 citations
    28. Defining the identity of mouse embryonic dermal fibroblasts Genesis · 2016 · 21 citations
    29. Epigenetic regulation in adult stem cells and cancers Cell & Bioscience · 2013 · 20 citations
    30. A novel and safe small molecule enhances hair follicle regeneration by facilitating metabolic reprogramming Experimental and Molecular Medicine · 2018 · 19 citations