TLDR TGF-β is crucial for controlling stem cell behavior and changes in its signaling can lead to diseases like cancer.
The 2012 review discussed the critical role of the TGF-β superfamily in stem cell biology, including embryonic, adult, and cancer stem cells. It detailed how TGF-β signaling pathways are essential for regulating stem cell self-renewal, differentiation, and maintenance, and how alterations in these pathways can lead to diseases like cancer. The review highlighted the complexity of TGF-β signaling, which involves multiple levels of control and varies between different types of stem cells, such as mouse and human embryonic stem cells, hematopoietic stem cells, and hair follicle stem cells. It also explored the paradoxical effects of TGF-β on stem cells, the crosstalk between different signaling pathways, and the interaction between TGF-β signaling and master transcription factors. The document emphasized the importance of understanding the intricate network of signals and transcriptional mechanisms that govern stem cell behavior for potential therapeutic applications in tissue maintenance and repair.
Cited in this study
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254 citations
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January 2012 in “Nature Reviews Molecular Cell Biology” Stem cell offspring help control their parent stem cells, affecting tissue health, healing, and cancer.
321 citations
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January 2012 in “Cell stem cell” TGF-β2 helps activate hair follicle stem cells by counteracting BMP signals.
191 citations
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September 2011 in “Cell stem cell” Hair follicle stem cells use specific chromatin changes to control their growth and differentiation.
499 citations
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September 2011 in “Cell” Fat-related cells are important for initiating hair growth.
260 citations
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June 2011 in “Cell” Wnt signaling is crucial for pigmented hair regeneration by controlling stem cell activation and differentiation.
396 citations
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May 2011 in “Cell stem cell” Nerve signals are crucial for hair follicle stem cells to become skin stem cells and help in wound healing.
314 citations
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April 2010 in “Developmental Cell” β-catenin in the dermal papilla is crucial for normal hair growth and repair.
1039 citations
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February 2009 in “Nature Reviews Molecular Cell Biology” Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.
788 citations
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February 2007 in “Nature” The document concludes that skin stem cells are important for hair growth and wound healing, and could be used in regenerative medicine.
211 citations
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October 2001 in “The FASEB Journal” Noggin is necessary to start the hair growth phase in skin after birth.