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GlossaryTranscription Factors

proteins that regulate gene expression by binding to DNA

Transcription Factors (TFs) are proteins that help turn specific genes on or off by binding to nearby DNA. They play a crucial role in regulating gene expression, ensuring that genes are activated at the right time and in the right cells, which is essential for processes like development, cell growth, and response to environmental signals.

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research Epithelial-To-Mesenchymal Transition in Cutaneous Wound Healing: Where We Are and Where We Are Heading

141 citations , August 2017 in “Developmental Dynamics”

The document concludes that a better understanding of cell changes during wound healing could improve treatments for chronic wounds and other conditions.

research Keratin 17 in Disease Pathogenesis: From Cancer to Dermatoses

62 citations , October 2018 in “Journal of pathology”

Keratin 17 is linked to various diseases, including cancer and skin conditions, and may be a target for diagnosis and treatment.

Post-Transcriptional Regulation of Keratinocyte Progenitor Cell Expansion, Differentiation, and Hair Follicle Regression by miR-22

research Post-Transcriptional Regulation of Keratinocyte Progenitor Cell Expansion, Differentiation, and Hair Follicle Regression by miR-22

52 citations , May 2015 in “PLOS Genetics”

miR-22, a type of microRNA, controls hair growth and its overproduction can cause hair loss, while its absence can speed up hair growth.

research A Preliminary Study of Differentially Expressed Genes in Expanded Skin and Normal Skin: Implications for Adult Skin Regeneration

16 citations , January 2011 in “Archives of Dermatological Research”

The study found that expanded skin regenerates similarly to normal skin, with 77 genes playing a role in the process.

research Desmoglein 4 Is Regulated by Transcription Factors Implicated in Hair Shaft Differentiation

35 citations , August 2009 in “Differentiation”

Desmoglein 4 is controlled by specific proteins that affect hair growth.

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community TWIST-1 and the cure: Is it really that easy?

in Research/Science 283 upvotes 3 years ago

TWIST-1 gene's role in hair loss and potential as a treatment target. Inhibiting TWIST-1 may prolong hair growth and reduce hair follicle sensitivity to DHT.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

nkrata in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community The most depressing things about hair loss for me

in Chat 24 upvotes 4 years ago

The emotional impact of hair loss and the risks associated with common treatments such as finasteride, dutasteride, minoxidil, RU58841, and Fluridil. People discussed their personal experiences with these treatments, including potential side effects and lowered fertility. Hair transplants were also mentioned as a possible solution.

community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 442 upvotes 4 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.

community The Real Cause Of Androgenetic Alopecia

in Research/Science 671 upvotes 1 year ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

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