New Research- Creatine Increasing Scalp DHT Without Corresponding Serum DHT Increase
Research/Science 5/22/2024
creatine DHT male pattern baldness MPB Minoxidil finasteride RU58841 PI3K/Akt Signaling Pathway phosphoinositide 3-kinase Akt pathway 5α-reductase androgen receptors AR mTOR Pathway MAPK/ERK Pathway mitogen-activated protein kinase extracellular signal-regulated kinase ERK pathway Nuclear Factor-kappa B Pathway NF-κB pathway inflammatory cytokines NADPH sex hormone-binding globulin SHBG albumin reactive oxygen species ROS type II 5α-reductase dutasteride topical minoxidil androgenic effects hormone expression testosterone hair follicles androgen metabolism protein synthesis cellular metabolism oxidative stress inflammation enzyme activity post-translational modifications phosphorylation acetylation ubiquitination carrier proteins hormone transport dynamics localized enzyme activity enhancement selective AR sensitization differential regulation of 5α-reductase isoenzymes localized inflammation localized oxidative stress intrafollicular DHT Rogaine Propecia RU mTOR ERK NF-κB Dut Min
Creatine may increase scalp DHT without affecting serum DHT, potentially speeding up male pattern baldness (MPB) for those genetically prone. Treatments mentioned include Minoxidil, finasteride, and RU58841.
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