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Glossary Enzyme Activity

rate at which an enzyme catalyzes a chemical reaction

Enzyme activity, also known as enzymatic activity or catalytic activity, refers to the rate at which an enzyme catalyzes a chemical reaction. It is a measure of how efficiently an enzyme converts substrates into products, often influenced by factors such as temperature, pH, and the presence of inhibitors or activators. This concept is crucial in understanding various biological processes, including those related to hair growth and alopecia, where specific enzymes play roles in follicle health and function.

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Research

5 / 1000+ results

research Local and Systemic Reduction by Topical Finasteride or Flutamide of Hamster Flank Organ Size and Enzyme Activity

37 citations , November 1995 in “Journal of Investigative Dermatology”

This study found that topical finasteride and flutamide both significantly reduced sebaceous gland growth and decreased prostatic weights in hamsters, indicating systemic effects despite local application.

research A Sensitive Assay for the Enzyme Activity in Hair Follicles and Epidermis that Catalyses the Peptidyl-Arginine-Citrulline Post-translational Modification

3 citations , April 2015 in “Current problems in dermatology”

This study focuses on improving the detection and characterization of an enzyme in guinea pig hair follicles that converts arginine to citrulline, highlighting challenges with assay sensitivity and reproducibility.

research Effects of Lavender Oil on Hair Growth-Relevant Enzyme Activity and Cytokine Expression in C57BL/6 Mice

1 citations , March 2016 in “Journal of Investigative Cosmetology”

This study found that lavender oil increased hair growth-related enzyme activity and cytokine expression, indicating potential hair growth-promoting effects in C57BL/6 mice.

research Phenolic composition, enzyme inhibitory, and antioxidant activity of Bituminaria bituminosa

6 citations , October 2016 in “Food Science and Biotechnology”

This study found that the water extract of Bituminaria bituminosa demonstrated the highest antioxidant activity and α-glucosidase inhibition among tested extracts, but no cholinesterase or tyrosinase inhibition.

research BIOCHEMICAL ANALYSIS OF HAIR GROWTH FROM THE ASPECTS OF AGING AND ENZYME ACTIVITIES

46 citations , February 1983 in “The Journal of Dermatology”

This study observed that hair regrowth in mice was irregular and delayed more in older mice, with increased enzyme activities in hair re-growing areas compared to non-growing areas.

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Community Join

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community Increasing activity of the sult1a1 enzyme via alkalizing agent and tretinoin for better response to topical minoxidil

in Research/Science 4 upvotes 2 years ago

Increasing the sult1a1 enzyme on the scalp may improve response to topical minoxidil. The user suggests using a baking soda solution, DMSO, and tretinoin to enhance enzyme activity and minoxidil effectiveness.

community Minoxidil + Tretinoin if you suspect you have low sulfotransferase enzyme activity

in Minoxidil 1 upvotes 1 year ago

Minoxidil may not be effective due to low sulfotransferase activity, and the user considers adding tretinoin to the regimen. They are unsure about the timing and combination with microneedling.

community You may not have the enzyme for topical minoxidil to work - a rarely talked about impact

100 upvotes 11 months ago

Some people may not respond to topical minoxidil due to low SULT1A1 enzyme activity, but oral minoxidil can be effective. Tretinoin may enhance minoxidil's effectiveness, and some users prefer oral minoxidil despite side effects.

community Do we know exactly why some people respond so great to dut/fin,min and others dont?

in Research/Science 29 upvotes 1 year ago

Genetic factors, enzyme activity, and DHT sensitivity affect individual responses to hair loss treatments like finasteride, minoxidil, and dutasteride. Starting treatments early can slow hair loss, but results vary among individuals.

community Did Tretinoin turn you into a minoxidil responder after not responding to minoxidil?

20 upvotes 1 year ago

Tretinoin may enhance the effectiveness of minoxidil for hair regrowth by increasing enzyme activity and skin permeability, but its standalone impact is limited. Some users experienced improved hair growth with tretinoin, while others found it worsened their condition.

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Learn

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learn Valproic acid

an anticonvulsant repurposed for hair loss via histone inhibition

learn Baricitinib

JAK inhibitor that reduces inflammation and immune attacks on hair follicles, leading to potential hair regrowth, especially in alopecia areata cases

learn Thymosin Beta 4

learn Stem Cell Factor

learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

learn procapil

Want to stop hormonal hair loss without touching your hormone levels? Procapil could block the enzyme doing the damage. Procapil's supplier describes it as inhibiting 5-alpha reductase at the scalp without changing hormone levels, but the published support is cell and animal work plus one small human study of a caffeine-plus-Procapil formula. It is a cosmetic ingredient, not an approved hair-loss treatment, and no trial has compared it with finasteride or minoxidil.

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