37 citations
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November 1995 in “Journal of Investigative Dermatology”
Topical finasteride and flutamide reduce gland size and enzymeactivity, with flutamide being more potent, potentially treating acne, seborrhea, hirsutism, and androgenic alopecia.
Increasing the sult1a1 enzyme on the scalp may improve response to topical minoxidil. The user suggests using a baking soda solution, DMSO, and tretinoin to enhance enzymeactivity and minoxidil effectiveness.
Minoxidil may not be effective due to low sulfotransferase activity, and the user considers adding tretinoin to the regimen. They are unsure about the timing and combination with microneedling.
A new product, Minoxidil booster, which enhances sulfotransferase enzymeactivity in the scalp, is now available. The user has started using this product, applied before Minoxidil, to improve their hair loss treatment results.
Genetic factors, enzymeactivity, and DHT sensitivity affect individual responses to hair loss treatments like finasteride, minoxidil, and dutasteride. Starting treatments early can slow hair loss, but results vary among individuals.
Tretinoin may enhance the effectiveness of minoxidil for hair regrowth by increasing enzymeactivity and skin permeability, but its standalone impact is limited. Some users experienced improved hair growth with tretinoin, while others found it worsened their condition.