The Effects of Biotin Supplementation on Serum and Liver Tissue Biotinidase Enzyme Activity and Alopecia in Rats Treated with Valproic Acid

    September 2008 in “ Brain & development ”
    Mutluay Arslan, Sebahattin Vurucu, Necati Balamtekin … Okan Ozcan
    Studysummary In this study on rats, valproic acid was associated with reduced biotinidase enzyme activity and higher alopecia rates, but biotin supplementation did not significantly affect alopecia occurrence.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on brainanddevelopment.com →
    Discuss this study in the Community →

    Research cited in this study 4

    1. Serum and Liver Tissue Biotinidase Enzyme Activity in Rats Administered Valproic Acid Brain & development · 2006
    2. Low Serum Biotinidase Activity in Children with Valproic Acid Monotherapy Epilepsia · 2001
    3. Possible Involvement of Partial Biotinidase Deficiency in Alopecia Areata Journal of the European Academy of Dermatology and Venereology · 1996
    4. Alopecia and Mood Stabilizer Therapy Annals of Clinical Psychiatry · 1996

    Related research 1

    1. Low Level of Maternal Biotin Intake Changes the Expression of Biotin Transporter in Dams and Fetuses in Mice 2014