Low Serum Biotinidase Activity in Children with Valproic Acid Monotherapy

    October 2001 in “ Epilepsia ”
    K. H. Schulpis, George A. Karikas, Joanna Tjamouranis … Stylianos Tsakiris
    Studysummary In this study, valproic acid treatment was associated with reduced biotinidase activity and improved skin lesions after biotin supplementation in children with seizures.
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    Research cited in this study 2

    1. Alopecia and Mood Stabilizer Therapy Annals of Clinical Psychiatry · 1996
    2. Partial Biotinidase Deficiency: Clinical and Biochemical Features The Journal of Pediatrics · 1990

    Related research 2

    1. Serum Biotinidase Activity in Children Treated With Valproic Acid and Carbamazepine Journal of child neurology · 2009
    2. Newborn Screening for Biotinidase Deficiency: Pilot Study and Follow-Up of Identified Cases Screening · 1992