Serum Biotinidase Activity in Children Treated With Valproic Acid and Carbamazepine

    May 2009 in “ Journal of child neurology ”
    Manuel Castro‐Gago, Carmen Gómez-Lado, Jesús Eirís-Puñal … Daisy E. Castiñeiras-Ramos
    Studysummary In this study, valproic acid treatment did not significantly affect serum biotinidase enzyme activity in children, but was associated with hair loss in some patients, which resolved with biotin supplementation.
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    Research cited in this study 3

    1. Serum and Liver Tissue Biotinidase Enzyme Activity in Rats Administered Valproic Acid Brain & development · 2006
    2. Low Serum Biotinidase Activity in Children with Valproic Acid Monotherapy Epilepsia · 2001
    3. Alopecia and Mood Stabilizer Therapy Annals of Clinical Psychiatry · 1996