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GlossaryHyperammonemia

condition with elevated ammonia levels in the blood

Hyperammonemia is a condition characterized by elevated levels of ammonia in the blood. Ammonia is a waste product that is typically processed by the liver and converted into urea, which is then excreted in urine. When the liver is unable to effectively process ammonia, due to liver disease or genetic disorders affecting the urea cycle, it can accumulate in the bloodstream and become toxic, potentially leading to neurological symptoms such as confusion, lethargy, and in severe cases, coma.

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research Hyperammonemia with Valproic Acid: Colonic Ischemia Associated with Triptan Use, Visual Side Effects with Pegylated Interferon, Alopecia Areata with Infliximab, and Adverse Effects Seen with Medications Used for Irritable Bowel Syndrome

2 citations , November 2004 in “Hospital pharmacy”

Certain medications can cause serious side effects, so it's important to report them.

research Treatment of Valproate-Induced Hyperammonemia

12 citations , May 2005 in “Journal of the American Geriatrics Society”

Stopping valproate and using lactulose can quickly treat valproate-induced hyperammonemia.

The Prevalence and Management of Side Effects of Lithium and Anticonvulsants as Mood Stabilizers in Bipolar Disorder from a Clinical Perspective

research The Prevalence and Management of Side Effects of Lithium and Anticonvulsants as Mood Stabilizers in Bipolar Disorder from a Clinical Perspective

65 citations , July 2013 in “International Clinical Psychopharmacology”

Mood stabilizers like lithium and anticonvulsants have side effects that can lead to patients stopping their medication, and managing these effects is important for treatment adherence.

research Serum Biotinidase Activity in Children Treated With Valproic Acid and Carbamazepine

16 citations , May 2009 in “Journal of child neurology”

Valproic acid does not change biotinidase enzyme activity in children's blood.

research Valproic Acid Is an Effective Anti-Emetic Treatment in Alexander Disease

April 2023 in “Neurology”

Valproic acid is a more effective treatment for vomiting in Alexander disease than other medications, with few side effects.

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community Better Than Minoxidil? Topical Sodium Valproate

in Research/Science 50 upvotes 9 months ago

Topical sodium valproate may promote hair growth by inhibiting GSK3β, allowing beta-catenin to proliferate, but it has potential side effects and requires more research. The conversation also mentions skepticism about a product called Vdphlo1, which includes sodium valproate and other ingredients.