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Glossary Valproic Acid

medication used to treat epilepsy and bipolar disorder

Valproic Acid, also known as VPA or by brand names like Depakote, is a medication primarily used to treat epilepsy, bipolar disorder, and to prevent migraine headaches. It works by increasing the levels of certain neurotransmitters in the brain, which helps stabilize electrical activity and mood. Additionally, Valproic Acid has been studied for its potential effects on hair growth, as it may influence pathways involved in hair follicle cycling.

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learn Valproic acid

an anticonvulsant repurposed for hair loss via histone inhibition

What is valproic acid, and how did it become a subject of interest in hair growth and alopecia research? Valproic acid is a prescription anticonvulsant that laboratory and mouse studies link to the Wnt/β-catenin hair-growth pathway; one small randomized trial of an 8.3% topical spray reported a hair-count gain over 24 weeks. Oral valproate is also a recognized cause of hair loss and a known teratogen.
How is valproic acid being explored differently in topical hair products compared to its traditional oral medical use? Topical valproic acid is being studied for local effects on the hair follicle rather than the whole-body effects of the oral drug. The human evidence is one small randomized 24-week trial of an 8.3% spray; no topical valproate product is approved for hair loss.
What biological mechanisms related to hair follicles are linked to valproic acid in experimental treatments? Valproic acid affects hair follicles by modulating cell signaling and gene regulation.
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Research

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research Valproic acid. A reappraisal of its pharmacological properties and clinical efficacy in epilepsy.

294 citations , February 1994 in “PubMed”

This review highlights valproic acid's efficacy and tolerability as a first-line treatment for various seizure types in both adults and children, emphasizing its minimal neurological adverse effects compared to other antiepileptic drugs.

research Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells

85 citations , April 2012 in “PLOS ONE”

This study found that valproic acid promoted hair re-growth in C3H mice by activating the Wnt/β-catenin pathway, suggesting its potential as a treatment for alopecia.

research Low Serum Biotinidase Activity in Children with Valproic Acid Monotherapy

73 citations , October 2001 in “Epilepsia”

In this study, valproic acid treatment was associated with reduced biotinidase activity and improved skin lesions after biotin supplementation in children with seizures.

research Pancreatitis associated with valproic acid therapy for epilepsy

73 citations , January 1980 in “Annals of Neurology”

This case report describes a child developing pancreatitis directly linked to valproic acid therapy.

research Transcutaneous implantation of valproic acid-encapsulated dissolving microneedles induces hair regrowth

68 citations , March 2018 in “Biomaterials”

This study found that in vivo, a novel microneedle system for valproic acid delivery may improve hair regrowth efficacy by upregulating hair follicle development pathways more effectively than topical application.

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Community Join

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community Source for topical valproic acid?

2 upvotes 8 months ago

The conversation is about finding a source for topical valproic acid for hair regrowth. The user mentions PP405 and the unavailability of products from certain suppliers.

community New & Improved Hair Growth Stack for Maximum Results

5 upvotes 1 year ago

A user shared a hair growth stack using minoxidil sulfate, valproic acid, bimatoprost, blue copper peptide, and other ingredients, emphasizing a gel-based formula for better skin tolerance. Another user suggested adding a 5-alpha-reductase inhibitor like finasteride or dutasteride for more effective long-term results.

community VDPHL-01 is Overrated and Ridiculous. This is just Oral Minoxidil.

in Research/Science 21 upvotes 1 year ago

VDPHL-01 is essentially a slow-release oral minoxidil, which is already known to work for hair growth. The formulation includes other ingredients like Medrogestone, Valproic acid, Setipiprant, and Cetirizine, but their effectiveness and necessity are questioned.

community Ordered PTD-DBM from tailor made

6 upvotes 5 years ago

The conversation discusses hair loss treatments, including finasteride, microneedling, minoxidil, and PTD-DBM. The user has not noticed significant regrowth and is considering cost-effective options like valproic acid.

community New company created by Dr. Kang-Yell Choi to commercialize PTD-DBM therapy

10 upvotes 6 years ago

PTD-DBM therapy for hair loss is being developed by Dr. Kang-Yell Choi, with human testing planned in South Korea. Some clinics in the U.S. offer PTD-DBM/valproic acid therapy, but it hasn't completed trials yet.

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