Valproic acid
aka - valproate
Valproic acid, first made in 1881 used since 1962, is primarily known for its use as an anticonvulsant and mood-stabilizing drug, and has recently garnered attention in the field of dermatology for its potential effects on hair growth and alopecia treatment. Scientifically, valproic acid operates by increasing the levels of gamma-aminobutyric acid (GABA) in the brain, but its effects on hair growth are thought to be mediated through different pathways, possibly involving the inhibition of histone deacetylases (HDAC) which can influence gene expression beneficial for hair follicle health and activity.
Research has highlighted valproic acid's capacity to induce hair regeneration in both animal models and human dermal papilla cells by activating alkaline phosphatase activity—an enzyme associated with hair growth and follicle development. Studies indicate that valproic acid can promote hair growth by elongating the hair shaft and delaying the transition to the catagen (regression) phase, alongside promoting the anagen (growth) phase in vivo, providing a promising avenue for alopecia treatment.
The community's engagement with valproic acid reflects a keen interest in its utility for hair loss, with discussions often revolving around personal experiences and the exploration of valproic acid as a novel treatment. Community members share anecdotal evidence of its efficacy, particularly when used topically, noting improvements in hair density and growth. However, experiences vary, and while some individuals report positive outcomes, others call for more extensive research to conclusively determine its effectiveness and optimal application methods.
In summary, valproic acid presents a promising, albeit still under-researched, option for treating alopecia by potentially enhancing hair growth and follicle health through mechanisms distinct from its neurological effects. While initial research and community experiences offer hope, the call for further scientific investigation is clear to fully establish valproic acid's role in hair loss therapy.
Research
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research Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells
research Valproic acid promotes human hair growth in in vitro culture model
research Exploring the Drug Repurposing Versatility of Valproic Acid as a Multifunctional Regulator of Innate and Adaptive Immune Cells
research Topical valproic acid increases the hair count in male patients with androgenetic alopecia: A randomized, comparative, clinical feasibility study using phototrichogram analysis
research Valproic acid reduces hair loss and improves survival in patients receiving temozolomide-based radiation therapy for high-grade glioma
research Risk of valproic acid-related alopecia: A systematic review and meta-analysis
research A case of androgenetic alopecia treated with valproic acid
research Valproic acid and alopecia: A two-edged sword
research Valproic acid-induced hair color change in an elderly male
research Faculty Opinions recommendation of Topical valproic acid increases the hair count in male patients with androgenetic alopecia: a randomized, comparative, clinical feasibility study using phototrichogram analysis.
research Transcutaneous implantation of valproic acid-encapsulated dissolving microneedles induces hair regrowth
research Fabrication of carboxymethyl cellulose/hyaluronic acid/polyvinylpyrrolidone composite pastes incorporation of minoxidil-loaded ferulic acid-derived lignin nanoparticles and valproic acid for treatment of androgenetic alopecia
research Commonly prescribed medications associated with alopecia
research Evaluation of Topical Sodium Valproate-Loaded Nano Spanlastics Formulation versus Minoxidil® 5% in The Treatment of Female Pattern Hair Loss Using Transdermal Delivery: A Comparative Study
research Severe hair loss associated with psyc hotropic drugs in psychiatric inpatients—Data from an observational pharmacovigilance program in German-speaking countries
research A case of telogen effluvium associated with drug-induced hyperprolactinemia.
research DRUG‐ASSOCIATED ALOPECIA
research Dissolving microneedles: Applications and growing therapeutic potential
research Targeting of CXXC5 by a Competing Peptide Stimulates Hair Regrowth and Wound-Induced Hair Neogenesis
