TLDR Valproic acid helped hair growth in alopecia patient; more research needed.
This article describes a case of a 60-year-old man with androgenetic alopecia who was treated with valproic acid (VPA), a mood stabilizer commonly used to treat epilepsy and bipolar disorders. While alopecia is a known adverse effect of VPA, this case report describes a peculiar case where VPA induced hair growth in the patient. The mechanism by which VPA prevents hair loss and promotes hair growth is not clear, but it is suspected that VPA can potentially have an effect on hair cycle and be applied to treat androgenetic alopecia with an unclear mechanism. This single case report calls for further investigation regarding the potential utility of VPA in the treatment of androgenetic alopecia.
85 citations,
April 2012 in “PLOS ONE” Valproic Acid helps regrow hair in mice and activates a hair growth marker in human cells.
36 citations,
October 2008 in “European journal of paediatric neurology” Valproic acid treatment may cause temporary hair loss due to reduced zinc and biotinidase levels, which tend to normalize after 6 months.
63 citations,
March 2000 in “Annals of clinical psychiatry” Some psychiatric medications can cause hair loss, but it usually grows back after adjusting the medication.
2 citations,
April 2017 in “Asian Journal of Psychiatry” Valproic acid can cause hair loss when taken orally but may promote hair growth when applied topically.
68 citations,
March 2018 in “Biomaterials” Tiny needles with valproic acid can effectively regrow hair.
Topical valproate can effectively promote hair growth.
37 citations,
June 2017 in “Journal of Investigative Dermatology” Blocking a protein called CXXC5 with a specific peptide can stimulate hair regrowth and new hair growth in wounds.
48 citations,
June 2013 in “Journal of Dermatological Science” Valproic acid may help hair grow and could be a safe treatment for hair loss.