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GlossaryValproic Acid (VPA)

medication used to treat epilepsy and bipolar disorder

Valproic Acid, also known as VPA or by brand names like Depakote, is a medication primarily used to treat epilepsy, bipolar disorder, and to prevent migraine headaches. It works by increasing the levels of certain neurotransmitters in the brain, which helps stabilize electrical activity and mood. Additionally, Valproic Acid has been studied for its potential effects on hair growth, as it may influence pathways involved in hair follicle cycling.

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Valproic Acid and/or Rapamycin Preconditioning Protects Hair Follicle Stem Cells from Oxygen Glucose Serum Deprivation-Induced Oxidative Injury via Activating Nrf2 Pathway

research Valproic Acid and/or Rapamycin Preconditioning Protects Hair Follicle Stem Cells from Oxygen Glucose Serum Deprivation-Induced Oxidative Injury via Activating Nrf2 Pathway

January 2024 in “PubMed”

Valproic acid and rapamycin protect hair follicle stem cells from damage by activating a protective pathway.

research Small RNAs Loom Large During Reprogramming

18 citations, June 2011 in “Cell stem cell”

MicroRNAs can reprogram cells into stem cells faster and more efficiently than traditional methods.

research Generation of iPS Cells from Human Hair Follicle Dermal Papilla Cells

8 citations, January 2014 in “PubMed”

Researchers made stem cells from human hair follicle cells with better efficiency than from skin cells.

The Role of Candidate Pharmacogenetic Variants in Determining Valproic Acid Efficacy, Toxicity, and Concentrations in Patients with Epilepsy

research The Role of Candidate Pharmacogenetic Variants in Determining Valproic Acid Efficacy, Toxicity, and Concentrations in Patients with Epilepsy

October 2024 in “Frontiers in Pharmacology”

Genetic variants can affect valproic acid's effectiveness, side effects, and levels in epilepsy treatment.

research Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells

85 citations, April 2012 in “PLOS ONE”

Valproic Acid helps regrow hair in mice and activates a hair growth marker in human cells.

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community Topical VPA - Anyone experiences here?

in Question 2 upvotes 6 years ago

The conversation is about using topical valproic acid (VPA) for hair loss, focusing on its application method, usage frequency, and combination with other treatments like micro-needling. No specific experiences with VPA were shared.

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