Valproate-Associated Transaminitis and Rhabdomyolysis

    April 2023 in “ Curēus ”
    Anupam Sharma, Jeannlis Sanchez, Madison Dew, Gursimran Shergill
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    TLDR Valproic acid can cause muscle damage and liver issues, which improve after stopping the drug.
    A 24-year-old man experienced mild transaminitis and rhabdomyolysis shortly after starting valproic acid for a seizure, which resolved after stopping the medication. While valproic acid commonly causes side effects like alopecia and gastrointestinal issues, it can also lead to serious conditions such as hepatotoxicity and rhabdomyolysis. The case highlights the need for prompt recognition and management of drug-induced myopathy and suggests monitoring creatinine kinase levels when beginning valproic acid treatment to prevent muscle damage and facilitate a quick transition to other treatments if necessary. Early intervention is key in treating valproate-induced myopathy to prevent severe outcomes.
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