Valproate-Associated Transaminitis and Rhabdomyolysis

    April 2023 in “ Curēus ”
    Anupam Sharma, Jeannlis Sanchez, Madison Dew, Gursimran Shergill
    Image of study
    TLDR Valproic acid can cause muscle damage and liver issues, which improve after stopping the drug.
    A 24-year-old man experienced mild transaminitis and rhabdomyolysis shortly after starting valproic acid for a seizure, which resolved after stopping the medication. While valproic acid commonly causes side effects like alopecia and gastrointestinal issues, it can also lead to serious conditions such as hepatotoxicity and rhabdomyolysis. The case highlights the need for prompt recognition and management of drug-induced myopathy and suggests monitoring creatinine kinase levels when beginning valproic acid treatment to prevent muscle damage and facilitate a quick transition to other treatments if necessary. Early intervention is key in treating valproate-induced myopathy to prevent severe outcomes.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 9 results

      community Here is my hair regrowth plan

      in Treatment  4 upvotes 4 years ago
      The user's hair regrowth plan includes topical treatments (RU58841, azelaic acid, ketoconazole), oral supplements (Gia Herbs, castor oil), microneedling, PTD-DBM peptide with valproic acid, red light therapy, inversion table with scalp massage, and platelet-rich fibrin injections. Commenters suggest that finasteride and minoxidil are essential treatments for male pattern hair loss, which are missing from the plan.

      community Anyone used Topical Calcipotriol (cream) or VPA ( Valproic Acid)

      in Chat  7 upvotes 3 years ago
      The conversation discusses using topical Calcipotriol and Valproic Acid for hair loss, focusing on their mechanisms involving the VDR receptor and Wnt/beta-catenin pathway. Specific treatments mentioned are Minoxidil, Finasteride, and RU58841.

      community Topical VPA - Anyone experiences here?

      in Question  2 upvotes 6 years ago
      The conversation is about using topical valproic acid (VPA) for hair loss, focusing on its application method, usage frequency, and combination with other treatments like micro-needling. No specific experiences with VPA were shared.

      community Figuring out my own experimental protocol

      in Treatment  9 upvotes 1 year ago
      User tries dermapen for hair loss and plans to use non-mainstream topicals like c60, ghk-cu, and ptd-dbm with valproic acid. They also use a head massager and modified LLLT belt for additional treatment.

    Similar Research

    5 / 437 results