Analysis of Adverse Drug Reactions in Pediatric Patients with Epilepsy: An Intensive Pharmacovigilance Study

    November 2023 in “ Children ”
    Eva García, Lizbeth Naranjo, Luz Adriana Pichardo‐Macías, María Josefa Bernad Bernad, Lucila I. Castro‐Pastrana, Matilde Ruiz García, Teresa Bernal, José M. Solı́s, David Calderón Guzmán, Luisa Díaz–García, Julieta Griselda Mendoza‐Torreblanca, Juan Luis Chávez‐Pacheco
    TLDR Many pediatric epilepsy patients experience preventable severe adverse drug reactions, especially with certain medications and risk factors.
    The study analyzed adverse drug reactions (ADRs) in 315 pediatric epilepsy patients over 112 months, identifying 548 ADRs in 211 patients. The most frequent ADRs were drowsiness, irritability, thrombocytopenia, and alopecia, primarily associated with valproic acid (VPA), levetiracetam (LEV), and phenytoin (PHT). Polytherapy and younger age were significant risk factors for ADRs, with malnutrition also contributing to severe ADRs. LEV and oxcarbazepine (OXC) caused more non-severe ADRs, while PHT caused more severe ADRs. Notably, most severe ADRs were preventable, highlighting the importance of intensive pharmacovigilance in improving medication safety in pediatric patients.
    Discuss this study in the Community →

    Research cited in this study

    3 / 3 results

    Related Community Posts Join

    6 / 1000+ results

      community Here is my hair regrowth plan

      in Treatment  3 upvotes 3 years ago
      The user's hair regrowth plan includes topical treatments (RU58841, azelaic acid, ketoconazole), oral supplements (Gia Herbs, castor oil), microneedling, PTD-DBM peptide with valproic acid, red light therapy, inversion table with scalp massage, and platelet-rich fibrin injections. Commenters suggest that finasteride and minoxidil are essential treatments for male pattern hair loss, which are missing from the plan.

      community Alopecia Areata Question

      in Treatment  2 upvotes 3 years ago
      A user with alopecia totalis, borderline universalis, seeks advice on getting into a Xeljanz trial or appealing insurance for coverage. They experienced significant hair regrowth but are now seeing hair loss again and want to try Xeljanz.

      community mbp alopecia areata or vitamin deficiency

      in Chat 4 months ago
      A 19-year-old male has been using topical finasteride and minoxidil for 8 months with no progress and is considering seeking a second opinion due to potential misdiagnosis. The discussion revolves around whether the hair loss is due to male pattern baldness, alopecia areata, or a vitamin deficiency.

      community Androgenic alopecia exclusively on the vertex of the scalp

      in Chat  6 upvotes 6 months ago
      A user experienced androgenic alopecia starting at the vertex without frontal hairline recession and is seeking information on this pattern. Another user noted that vertex or diffuse hair loss is common among men.

      community Fibrosing alopecia in a pattern distribution

      in Research/Science  14 upvotes 8 months ago
      A user has been experiencing hair loss for 4 years, with treatments like minoxidil, finasteride, and various supplements proving ineffective. They were diagnosed with fibrosing alopecia in a pattern distribution, a condition that may require a combination of anti-inflammatory and hair growth treatments.

    Similar Research

    5 / 1000+ results