Inhibition of 3-Methylcrotonyl-CoA Carboxylase Explains the Increased Excretion of 3-Hydroxyisovaleric Acid in Valproate-Treated Patients

    December 2011 in “ Journal of inherited metabolic disease ”
    Paula B. Luis, J. P. N. Ruiter, Lodewijk IJlst … Margarida F. B. Silva
    Studysummary This study found that valproic acid may interfere with the leucine metabolic pathway by inhibiting 3-methylcrotonyl-CoA carboxylase and biotinidase, which could contribute to side effects like skin rash and hair loss in patients.
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    Research cited in this study 6

    1. Serum Biotinidase Activity in Children Treated With Valproic Acid and Carbamazepine Journal of child neurology · 2009
    2. The Influence of Valproic Acid Treatment on Hair and Serum Zinc Levels and Serum Biotinidase Activity European journal of paediatric neurology · 2008
    3. The Effects of Biotin Supplementation on Serum and Liver Tissue Biotinidase Enzyme Activity and Alopecia in Rats Treated with Valproic Acid Brain & development · 2008
    4. Serum and Liver Tissue Biotinidase Enzyme Activity in Rats Administered Valproic Acid Brain & development · 2006
    5. Low Serum Biotinidase Activity in Children with Valproic Acid Monotherapy Epilepsia · 2001
    6. Alopecia and Mood Stabilizer Therapy Annals of Clinical Psychiatry · 1996