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Inhibition of 3-Methylcrotonyl-CoA Carboxylase Explains the Increased Excretion of 3-Hydroxyisovaleric Acid in Valproate-Treated Patients

research Inhibition of 3-Methylcrotonyl-CoA Carboxylase Explains the Increased Excretion of 3-Hydroxyisovaleric Acid in Valproate-Treated Patients

20 citations , December 2011 in “Journal of inherited metabolic disease”

Valproic acid treatment increases a specific acid in urine by blocking an enzyme, possibly causing skin rash and hair loss.

The Role of Candidate Pharmacogenetic Variants in Determining Valproic Acid Efficacy, Toxicity, and Concentrations in Patients with Epilepsy

research The Role of Candidate Pharmacogenetic Variants in Determining Valproic Acid Efficacy, Toxicity, and Concentrations in Patients with Epilepsy

October 2024 in “Frontiers in Pharmacology”

Genetic variants can affect valproic acid's effectiveness, side effects, and levels in epilepsy treatment.

research Compilation of a Comprehensive Gene Panel for Systematic Assessment of Genes That Govern an Individual’s Drug Responses

13 citations , October 2010 in “Pharmacogenomics”

Researchers found that most genes affecting drug responses are not fully covered by commercial SNP chips, suggesting the need for more comprehensive tools to optimize drug selection based on genetics.

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