The Role of Candidate Pharmacogenetic Variants in Determining Valproic Acid Efficacy, Toxicity, and Concentrations in Patients with Epilepsy

October 2024 in “ Frontiers in Pharmacology ”

Hady Yazbeck, Joe Youssef, Wassim Nasreddine, Abdallah Kurdi, Nathalie K. Zgheib, Ahmad Beydoun

valproic acid VPA pharmacogenetic variants rs1137101 LEPR hair loss rs4880 SOD2 rs3892097 CYP2D6 rs1057910 CYP2C9*3

Studysummary This study found that in patients with genetic generalized epilepsies, certain gene variants were linked to differences in valproic acid treatment outcomes, including a higher likelihood of treatment failure, varying serum drug concentrations, and specific side effects like weight gain and hair loss.

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