2 citations
,
April 2017 in “Asian Journal of Psychiatry” This review discusses the role of histone deacetylases in hearing loss, proposing potential pharmacological interventions, but reports no new clinical results.
9 citations
,
January 2015 in “Indian Journal of Pharmacology/The Indian journal of pharmacology” This study reports that alopecia may develop in patients with chronic exposure to high plasma concentrations of valproate, but resolved after dose reduction or treatment discontinuation.
46 citations
,
December 2014 in “Epilepsy & behavior” This study found that weight gain and alopecia were the most common cosmetic side effects of AEDs, with valproic acid and pregabalin being particularly associated with these effects.
37 citations
,
February 2014 in “Journal of Dermatology” This study found that topical valproic acid significantly increased hair count in male patients with moderate androgenetic alopecia compared to placebo over 24 weeks.
6 citations
,
April 2013 in “International Journal of Dermatology” This correspondence article discusses a case of androgenetic alopecia treated with valproic acid but does not present new clinical findings.
61 citations
,
January 2013 in “Indian Journal of Dermatology, Venereology and Leprology” This review discusses the causes, clinical presentation, and management of anagen effluvium, emphasizing its psychological impact and the need for empathy and practical support, but reports no new results.
17 citations
,
January 2013 in “Indian Journal of Pharmacology” This case report highlights an interest in exploring the relationship between serum levels of sodium valproate and hair loss, though no case reports currently establish this link.
85 citations
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April 2012 in “PLOS ONE” This study found that valproic acid promoted hair re-growth in C3H mice by activating the Wnt/β-catenin pathway, suggesting its potential as a treatment for alopecia.
16 citations
,
May 2009 in “Journal of child neurology” In this study, valproic acid treatment did not significantly affect serum biotinidase enzyme activity in children, but was associated with hair loss in some patients, which resolved with biotin supplementation.
36 citations
,
October 2008 in “European journal of paediatric neurology” This study found that pediatric patients on valproic acid may experience hair loss due to reduced zinc and biotinidase levels within the first 3 months, with zinc depletion continuing to contribute by the 6th month.
17 citations
,
January 2008 in “Journal of the American Academy of Dermatology” Valproic acid can cause hair loss, but information on hair color change is not detailed.
13 citations
,
January 2007 in “Epilepsia” This case report describes a 47-year-old woman who experienced reversible curling of her hair during treatment with valproic acid, suggesting potential side effects on hair texture.
15 citations
,
May 2006 in “Brain & development” The authors concluded that administering biotin may help prevent alopecia caused by reduced biotinidase activity during valproic acid therapy in rats.
16 citations
,
October 2004 in “Acta dermato-venereologica” This article provides information about the University of Bologna's departments involved and includes contact details for the lead author, but it presents no research findings.
73 citations
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October 2001 in “Epilepsia” In this study, valproic acid treatment was associated with reduced biotinidase activity and improved skin lesions after biotin supplementation in children with seizures.
16 citations
,
October 1994 in “PubMed” This review, drawing on literature and personal experience, suggests that sodium valproate is a safe and effective antiepileptic drug for various epileptic conditions in children and adults, including the elderly.