Valproate: Its Effects on Hair

    January 2018 in “ International journal of trichology ”
    Anil Kakunje, Ashwini Prabhu, ES Sindhu Priya, Ravichandra Karkal, Parmod Kumar, Nitin Gupta, P. K. Rahyanath
    TLDR Valproate can cause hair loss and changes in hair appearance, but may help regrow hair when applied topically.
    The document discussed the dualistic effects of valproate on hair, noting that while oral valproate, used for epilepsy and bipolar disorder, could cause reversible hair loss in up to 12% of users, topical valproate showed potential for promoting hair regeneration. Hair loss from oral valproate was dose-related and included changes in hair texture and color. Conversely, studies, including a clinical study on male patients with androgenetic alopecia, indicated that topical valproate increased hair count and activated hair growth mechanisms. Further research was needed to fully understand these contrasting effects.
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