Valproate-Associated Hair Abnormalities: Pathophysiology and Management Strategies
September 2021
in “
Human Psychopharmacology: Clinical and Experimental
”
TLDR Valproate can cause hair problems, but there are ways to manage them.
Research cited in this study
22 / 22 resultsresearch Valproate Induced Hair Loss and Curly Hair in Bipolar Disorder
Valproate can cause both hair loss and curly hair in bipolar disorder patients.
research Telogen Effluvium: A Comprehensive Review
The document concludes that Telogen Effluvium is a hair loss disorder that can be assessed with the modified wash test and may be treated with clobetasol foam, with patient management being important.
research Risk of Valproic Acid-Related Alopecia: A Systematic Review and Meta-Analysis
Valproic acid increases the risk of hair loss more than other drugs, especially in migraine patients, and lamotrigine may be a safer alternative.
research Valproate: Its Effects on Hair
Valproate can cause hair loss and changes in hair appearance, but may help regrow hair when applied topically.
research A Case Report of Biotin Treatment for Valproate-Induced Hair Loss
Biotin may effectively treat hair loss caused by valproate medication.
research Valproic Acid and Alopecia: A Two-Edged Sword
Valproic acid can cause hair loss when taken orally but may promote hair growth when applied topically.
research Diet and Hair Loss: Effects of Nutrient Deficiency and Supplement Use
Correcting nutrient deficiencies may help with hair loss, but the benefits of supplements without a deficiency are uncertain and could be harmful.
research Agomelatine May Alleviate Valproate-Induced Hair Loss
Agomelatine might help stop hair loss caused by valproate.
research Curly Hair Induced by Valproate in Bipolar Disorder
Valproate can cause rare hair curling in some patients.
research Hair Care and Dyeing: Impact on Alopecia
Gentle hair care and avoiding harsh treatments can help manage hair loss.
research Cosmetic Side Effects of Antiepileptic Drugs in Adults With Epilepsy
Some antiepileptic drugs can cause weight gain and hair loss, especially in women.
research Aromatase Inhibitors Induce Male Pattern Hair Loss in Women
Aromatase inhibitors cause male pattern hair loss in women.
research Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells
Valproic Acid helps regrow hair in mice and activates a hair growth marker in human cells.
research Serum Biotinidase Activity in Children Treated With Valproic Acid and Carbamazepine
Valproic acid does not change biotinidase enzyme activity in children's blood.
research The Therapeutic Effect and Changed Serum Zinc Level After Zinc Supplementation in Alopecia Areata Patients with Low Serum Zinc Level
Zinc supplements increased zinc levels in some hair loss patients but didn't significantly improve hair growth.
research The Influence of Valproic Acid Treatment on Hair and Serum Zinc Levels and Serum Biotinidase Activity
Valproic acid treatment may cause temporary hair loss due to reduced zinc and biotinidase levels, which tend to normalize after 6 months.
research The Effects of Biotin Supplementation on Serum and Liver Tissue Biotinidase Enzyme Activity and Alopecia in Rats Treated with Valproic Acid
Biotin supplements increased biotin levels but did not significantly prevent hair loss in rats on valproic acid.
research Valproate-Induced Change in Hair Color
Valproic acid can cause hair loss, but information on hair color change is not detailed.
research Serum and Liver Tissue Biotinidase Enzyme Activity in Rats Administered Valproic Acid
Valproic acid may cause hair loss by reducing biotinidase enzyme activity in rats.
research The Diagnosis and Treatment of Iron Deficiency and Its Potential Relationship to Hair Loss
Iron deficiency may be related to hair loss, but there's not enough evidence to recommend iron screening or supplements for all hair loss patients.
research Hair Loss in Psychopharmacology
Some psychiatric medications can cause hair loss, but stopping or reducing the dose usually reverses it.
research Alopecia and Mood Stabilizer Therapy
Hair loss from mood stabilizers is common but can be managed without stopping the medication.
Related Community Posts Join
6 / 11 resultscommunity Found the solution tressbros - 1.5 years 2.5mg oral minox, 5mg finasteride, 8mg estradiol valerate (weekly)
The conversation discusses a transgender individual's successful hair loss treatment over 1.5 years using 2.5mg oral minoxidil, 5mg finasteride, and 8mg weekly injectable estradiol valerate. Some users debate the appropriateness of this approach within the group's goals, while others support the individualized treatment and its additional benefits for transgender individuals.
community Topical Valproic acid/sodium valproate — has anyone tried this?
The conversation is about using valproic acid, an anti-seizure medication, as a topical treatment to promote hair growth. The original poster is seeking personal experiences from those who have tried this method.
community FtM: "Aggressive Regemin - Recovery From Norwood-6.5" Minoxodil/Estradiol valerate/Spironolactone. (What will happen in the worst case if CIS male go this way for a year?)
User "Ant1pal" shares progress pictures of hair regrowth using Minoxidil, Estradiol valerate, and Spironolactone. Users discuss potential side effects and the possibility of localizing estrogen to hair follicles for better treatment.
community Question.. ( Come check )
A user has been losing hair for two and a half years after a tropical trip and illness. A dermatologist prescribed betamethasone valerate 0.1% lotion, but the user is unsure if it's safe or effective for general hair loss.
community How effective is spironolactone?
A 21-year-old MTF individual is experiencing rapid hair thinning and is currently on estradiol valerate. They are inquiring about the effectiveness of spironolactone for hair loss, despite being aware of its serious side effects.
community I'm 27 f with major hairloss, should my dermatologist be doing more?
A 27-year-old woman experiencing significant hair loss is using spironolactone, Nizoral shampoo, and betamethasone valerate. She questions the effectiveness of these treatments and whether she should seek another dermatologist.
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