Valproate-Associated Hair Abnormalities: Pathophysiology and Management Strategies

    September 2021 in “ Human Psychopharmacology: Clinical and Experimental ”
    Samir Kumar Praharaj, Ravindra N Munoli, S. L. Udupa, Sivapriya Vaidyanathan
    Studysummary This review discusses valproate-associated hair abnormalities, describing their common and benign nature, and outlines management strategies, though new clinical results are not provided.
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    Research cited in this study 24

    1. Valproate Induced Hair Loss and Curly Hair in Bipolar Disorder Clinical psychopharmacology and neuroscience/Clinical Psychopharmacology and Neuroscience · 2019
    2. Telogen Effluvium: A Comprehensive Review Clinical, Cosmetic and Investigational Dermatology · 2019
    3. Risk of Valproic Acid-Related Alopecia: A Systematic Review and Meta-Analysis Seizure · 2019
    4. Valproate: Its Effects on Hair International journal of trichology · 2018
    5. A Case Report of Biotin Treatment for Valproate-Induced Hair Loss The Journal of Clinical Psychiatry · 2017
    6. Valproic Acid and Alopecia: A Two-Edged Sword Asian Journal of Psychiatry · 2017
    7. Diet and Hair Loss: Effects of Nutrient Deficiency and Supplement Use Dermatology practical & conceptual · 2017
    8. Agomelatine May Alleviate Valproate-Induced Hair Loss Düşünen Adam · 2017
    9. Curly Hair Induced by Valproate in Bipolar Disorder Clinical psychopharmacology and neuroscience/Clinical Psychopharmacology and Neuroscience · 2016
    10. Hair Care and Dyeing: Impact on Alopecia Current problems in dermatology · 2015
    11. Cosmetic Side Effects of Antiepileptic Drugs in Adults With Epilepsy Epilepsy & behavior · 2014
    12. Aromatase Inhibitors Induce Male Pattern Hair Loss in Women Annals of Oncology · 2013
    13. Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells PLOS ONE · 2012
    14. Does D Matter? The Role of Vitamin D in Hair Disorders and Hair Follicle Cycling Dermatology Online Journal · 2010
    15. Serum Biotinidase Activity in Children Treated With Valproic Acid and Carbamazepine Journal of child neurology · 2009
    16. The Therapeutic Effect and Changed Serum Zinc Level After Zinc Supplementation in Alopecia Areata Patients with Low Serum Zinc Level Annals of Dermatology · 2009
    17. The Influence of Valproic Acid Treatment on Hair and Serum Zinc Levels and Serum Biotinidase Activity European journal of paediatric neurology · 2008
    18. The Effects of Biotin Supplementation on Serum and Liver Tissue Biotinidase Enzyme Activity and Alopecia in Rats Treated with Valproic Acid Brain & development · 2008
    19. Valproate-Induced Change in Hair Color Journal of the American Academy of Dermatology · 2008
    20. Serum and Liver Tissue Biotinidase Enzyme Activity in Rats Administered Valproic Acid Brain & development · 2006
    21. The Diagnosis and Treatment of Iron Deficiency and Its Potential Relationship to Hair Loss Journal of The American Academy of Dermatology · 2006
    22. Hair Loss in Psychopharmacology Annals of Clinical Psychiatry · 2000
    23. Alopecia and Mood Stabilizer Therapy Annals of Clinical Psychiatry · 1996
    24. Change in Hair Color Induced by Valproic Acid Developmental Medicine & Child Neurology · 1981

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    6. Diagnosis of Hair Loss: Clinical Features of Common Causes PubMed · 1992
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