A Case Report of Biotin Treatment for Valproate-Induced Hair Loss

August 2017 in “ The Journal of Clinical Psychiatry ”

Koen P. Grootens, Erwin G. Th. M. Hartong

biotin valproate telogen effluvium hair loss bipolar disorder vitamin B7

From the encyclopedia

Biotin →

supplement to help with hair texture and quality

Valproic acid →

an anticonvulsant repurposed for hair loss via histone inhibition

Studysummary In this letter, excessive hair loss due to telogen effluvium was observed as a distressing side effect in the early months of valproate treatment, potentially linked to disruption in biotin metabolism, although the exact mechanism remains unclear.

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