Efficacy of Systemic Minoxidil and Tofacitinib Combination in Treatment-Resistant Alopecia Universalis

The document presents a case study of a 31-year-old male patient with treatment-resistant alopecia universalis (AU), a severe form of hair loss. The patient was successfully treated with a combination of tofacitinib and oral minoxidil after other treatments failed to show results. The patient's Severity of Alopecia Tool Score (SALT) improved from 100 to 35 after the treatment. The study concludes that the combination of tofacitinib and oral minoxidil may be an effective alternative treatment approach in severe alopecia areata (AA) cases. However, it suggests that further studies are necessary to confirm this result.