Zinc as an Ambivalent but Potent Modulator of Murine Hair Growth In Vivo: Preliminary Observations

    October 2005 in “ Experimental Dermatology ”
    Przemysław M. Płonka, Bori Handjiski, Małgorzata Popik … Ralf Paus
    Studysummary This study found that high-dose oral zinc significantly influences hair growth in mice, showing both inhibition and promotion effects depending on the timing and duration of administration.
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    Research cited in this study 15

    1. A Guide to Assessing Damage Response Pathways of the Hair Follicle: Lessons From Cyclophosphamide-Induced Alopecia in Mice Journal of Investigative Dermatology · 2005
    2. Limitations of Human Occipital Scalp Hair Follicle Organ Culture for Studying the Effects of Minoxidil as a Hair Growth Enhancer Experimental Dermatology · 2004
    3. GLI2 Is Expressed in Normal Human Epidermis and Basal Cell Carcinoma and Induces GLI1 Expression by Binding to Its Promoter Journal of Investigative Dermatology · 2004
    4. Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
    5. Topical Estrogen Accelerates Hair Regrowth in Mice After Chemotherapy-Induced Alopecia by Favoring the Dystrophic Catagen Response Pathway to Damage Journal of Investigative Dermatology · 2004
    6. Atrichia With Papular Lesions Resulting From a Novel Homozygous Missense Mutation in the Hairless Gene Clinical and Experimental Dermatology · 2003
    7. The Effects of Minoxidil, 1% Pyrithione Zinc, and a Combination of Both on Hair Density: A Randomized Controlled Trial British Journal of Dermatology · 2003
    8. Stress Inhibits Hair Growth in Mice by Inducing Premature Catagen Development and Harmful Perifollicular Inflammatory Events via Neuropeptide Substance P-Dependent Pathways American Journal of Pathology · 2003
    9. Indications for a Brain-Hair Follicle Axis: Inhibition of Keratinocyte Proliferation and Up-Regulation of Keratinocyte Apoptosis in Telogen Hair Follicles by Stress and Substance P The FASEB Journal · 2001
    10. Optic Nerve Changes in Zinc-Deficient Rats Experimental Eye Research · 2001
    11. Correlation of Proteolytic Activities of Organ Cultured Intact Mouse Skin With Defined Hair Cycle Stages Journal of Dermatological Science · 1994
    12. Melanogenesis During the Anagen-Catagen-Telogen Transformation of the Murine Hair Cycle ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1994
    13. Coarse to Fine Hair Conversion Induced by Zinc in C57/6J Mice The Tohoku Journal of Experimental Medicine · 1992
    14. Alopecia Induced in Young Mice by Exposure to Excess Dietary Zinc Experientia · 1986
    15. Zinc Metabolism in Lethal-Milk Mice Journal of Heredity · 1984

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    5. Protection Against Chemotherapy-Induced Alopecia: Targeting ATP-Binding Cassette Transporters in the Hair Follicle Trends in pharmacological sciences · 2013
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