Coarse to Fine Hair Conversion Induced by Zinc in C57/6J Mice

Chronic administration of zinc chloride in C57/6J mice over 25 days, at doses of 11 to 56 micrograms/g body weight, 5 times per week, resulted in the replacement of long coarse hairs with short fine (vello) hairs. The skin's histological architecture remained normal, except that hair follicles were confined to the dermis and did not extend into the hypodermis.