Secretory Phospholipase A2-IIA Overexpressing Mice Exhibit Cyclic Alopecia Mediated Through Aberrant Hair Shaft Differentiation and Impaired Wound Healing Response

September 2017 in “ Scientific Reports ”

Gopal Chovatiya, Rahul M. Sarate, Raghava R. Sunkara, Nilesh P. Gawas, Vineet Kala, Sanjeev K. Waghmare

TLDR Mice with too much sPLA₂-IIA have hair loss and poor wound healing due to abnormal hair growth and stem cell depletion.

The study focused on the effects of secretory phospholipase A2-IIA (sPLA₂-IIA) overexpression in mice and its link to cyclic alopecia and wound healing. Overexpression of sPLA₂-IIA in homozygous mice led to a disrupted hair follicle cycle, resulting in cyclic alopecia due to the exhaustion of the hair follicle stem cell pool by postnatal day 28. The mice exhibited aberrant hair shaft differentiation, with downregulation of key genes (Sox21, Msx2, Foxn1, Gata3, Krt82, Krt71) and signaling modulators (BMP4, Lef1, Shh). Additionally, these mice had an impaired initial wound healing response. The study concluded that sPLA₂-IIA overexpression causes abnormal hair shaft differentiation and impaired wound healing, potentially due to deregulated signaling and depletion of hair follicle stem cells. The number of mice used in the study was not specified in the summary provided.

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Secretory Phospholipase A2-IIA Overexpressing Mice Exhibit Cyclic Alopecia Mediated Through Aberrant Hair Shaft Differentiation and Impaired Wound Healing Response

Research cited in this study

research sPLA2-IIA Overexpression in Mice Epidermis Depletes Hair Follicle Stem Cells and Induces Differentiation Mediated Through Enhanced JNK/c-Jun Activation

research Increased Susceptibility to Skin Carcinogenesis Associated with a Spontaneous Mouse Mutation in the Palmitoyl Transferase Zdhhc13 Gene

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research Hair Follicular Expression and Function of Group X Secreted Phospholipase A2 in Mouse Skin

research Bone Morphogenetic Protein Antagonist Noggin Promotes Skin Tumorigenesis Via Stimulation Of The Wnt And Shh Signaling Pathways

research Epidermal Stem Cell Diversity and Quiescence

research The Disruption of Sox21-Mediated Hair Shaft Cuticle Differentiation Causes Cyclic Alopecia in Mice

research Disruption of Smad4 in Mouse Epidermis Leads to Depletion of Follicle Stem Cells

research Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding

research The Hair Cycle

research The Hair Cycle

research Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis

research Manipulation of Stem Cell Proliferation and Lineage Commitment: Visualization of Label-Retaining Cells in Wholemounts of Mouse Epidermis

research Epidermal Growth Factor as a Biological Switch in Hair Growth Cycle

research Expression of Enhancing Factor/Phospholipase A2 in Skin Results in Abnormal Epidermis and Increased Sensitivity to Chemical Carcinogenesis

research Cyclic Alopecia in Msx2 Mutants: Defects in Hair Cycling and Hair Shaft Differentiation

research Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis

research Expression of a Dominant Negative Mutant of Epidermal Growth Factor Receptor in the Epidermis of Transgenic Mice Elicits Striking Alterations in Hair Follicle Development and Skin Structure.

research The Secret Life of the Hair Follicle

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