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Glossary Hair Shaft Differentiation

process where hair follicle cells form distinct hair layers

Hair Shaft Differentiation refers to the process by which cells in the hair follicle transform into the distinct layers that make up the hair shaft. This involves the specialization of cells into the medulla, cortex, and cuticle, each contributing to the hair's structure, strength, and appearance. This process is crucial for the proper formation and function of hair.

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Research

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research `Cyclic alopecia' inMsx2mutants: defects in hair cycling and hair shaft differentiation

158 citations , December 2002 in “Development”

In this study, Msx2-deficient mice showed progressive hair loss due to shortened anagen phase and prolonged catagen and telogen phases, resulting in cyclic alopecia with structurally abnormal hair shafts.

research EGFR Controls Hair Shaft Differentiation in a p53-Independent Manner

13 citations , April 2019 in “iScience”

In this study, researchers observed that EGFR deficiency in the epidermis affects gene expression related to cell differentiation and structure, highlighting spatial and temporal roles of EGFR during skin and hair follicle development.

Secretory Phospholipase A2-IIA Overexpressing Mice Exhibit Cyclic Alopecia Mediated Through Aberrant Hair Shaft Differentiation and Impaired Wound Healing Response

research Secretory phospholipase A2-IIA overexpressing mice exhibit cyclic alopecia mediated through aberrant hair shaft differentiation and impaired wound healing response

7 citations , September 2017 in “Scientific Reports”

This study found that overexpression of sPLA2-IIA in homozygous mice resulted in cyclic alopecia, a halt in hair follicle cycling, and impaired wound healing due to complete loss of hair follicle stem cells.

research Generation of iPS-derived model cells for analyses of hair shaft differentiation

2 citations , September 2017 in “Biotechniques/BioTechniques”

This study developed a stable cell line model to evaluate hair differentiation activity, offering a new tool for screening drugs that promote hair growth using mouse iPS cell-derived systems.

research Transgenic Kallikrein 14 Mice Display Major Hair Shaft Defects Associated with Desmoglein 3 and 4 Degradation, Abnormal Epidermal Differentiation, and IL-36 Signature

15 citations , June 2020 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study identifies KLK14 as a significant factor contributing to hair defects and skin inflammation in a mouse model of Netherton syndrome.

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Community Join

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community Iron Deficiency Hair Loss vs Androgenetic Alopecia

5 upvotes 3 years ago

Iron deficiency can mimic androgenetic alopecia (AGA) and cause hair loss, but it is rare in men. Recovery is possible with supplements if iron deficiency is the cause, but genetic hair loss may still progress.

community Solving Hair Loss with Research at MIT

in Research/Science 595 upvotes 1 year ago

Hair loss treatments like minoxidil, finasteride, TDM-105795, and PP405. MIT is hosting a hackathon to find innovative hair loss solutions.

community Prolactin the Cause of Hair Loss? ABS-201 the Cure?

29 upvotes 2 months ago

Prolactin may contribute to hair loss, but targeting its receptor won't cure androgenetic alopecia. ABS-201 could be a useful alternative or adjuvant therapy, similar to JAK inhibitors, but not more effective than HMI-115.

community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 3 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

community Is this true? It can be a major breakthrough

1008 upvotes 5 months ago

Deoxyribose sugar gel may stimulate hair regrowth similarly to minoxidil by enhancing blood supply and follicle activity. Human trials are necessary, and current products have mixed results.

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Learn

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Thymosin Beta 4

learn Epidermal Growth Factor

learn Stem Cell Factor

learn Cetirizine

How does cetirizine reduce inflammation linked to hair loss? Cetirizine is proposed to lower prostaglandin D2 and raise prostaglandin E2 around hair follicles; three small trials of a compounded 1% topical report modest increases in hair density and shaft thickness, with minoxidil doing better head-to-head. Topical cetirizine is off-label and unapproved for hair loss, and the evidence is too thin to call it effective or safe.

learn Hair Multiplication

extract, clone, and reinsert your own hair cells

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SMP Specialist
Hairo Fallas
Newark, NJ, United States

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Hairo Fallas