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    GlossaryFollicular Differentiation

    process where hair follicle cells become specialized for hair growth

    Follicular differentiation is the process by which cells in the hair follicle develop into specialized types that contribute to hair growth. This involves the transformation of stem cells into various cell types, such as those forming the hair shaft, inner root sheath, and sebaceous glands, each playing a crucial role in the structure and function of the hair.

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      learn Tretinoin

      the gold standard retinoid in dermatology that's also helpful for hair regrowth alongside Minoxidil

      learn HMI-115

      much-hyped research compound targeting prolactin receptor in scalp

      learn GHK-Cu

      a copper peptide showing promise in both regrowth and reversing gray hair

      learn Caffeine

      the stimulant you know and love can be used topically to stimulate hair

      learn Minoxidil

      An essential vasodilator with some anti-androgenic effects, has excellent safety record

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      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  44 upvotes 4 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

      community Verteporfin and Microneedling

      in Treatments 5 months ago
      Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.

      community DHT is about to get smashed ….

      in Update  802 upvotes 2 months ago
      The conversation discusses hair loss treatments like topical finasteride with minoxidil, oral dutasteride, and essential oils. Oral treatments like dutasteride and finasteride are seen as more effective, though some prefer topicals to avoid side effects.

      community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

      in Research/Science  732 upvotes 2 years ago
      A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.