TLDR Keratoacanthoma changes as it grows, showing different hair follicle characteristics at each stage.
The study investigated the expression of follicular markers in keratoacanthoma (KA) across different stages, analyzing 67 tumors. It found that CK15 (clone C8/144B), CK19, and CD34 were not expressed at any stage, while CK1, CK10, CK16, CK17, CK15 (clone LHK15), and calretinin showed stage-dependent expression changes. The results indicated that KA is a follicular neoplasm with infundibular/isthmic differentiation, with early-stage tumors showing infundibular differentiation and well-developed tumors exhibiting isthmic differentiation. In the regressed stage, KAs lost follicular differentiation features and displayed epidermal characteristics. The absence of CK15 (clone C8/144B) expression did not entirely dismiss a connection between KA regression and the hair follicle cycle.
45 citations
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February 2013 in “The Journal of Dermatology” Keratoacanthoma and some squamous cell carcinomas are linked to hair follicles, while others are not.
33 citations
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April 2012 in “British Journal of Dermatology” Damaged hair follicle stem cells can cause permanent hair loss, but understanding their role could lead to new treatments.
34 citations
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February 2012 in “American Journal of Dermatopathology” Calretinin can help identify certain skin structures and tumors.
120 citations
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August 2008 in “The journal of investigative dermatology/Journal of investigative dermatology” Cytokeratin 19 and cytokeratin 15 are key markers for monitoring the quality and self-renewing potential of engineered skin.
26 citations
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June 2005 in “British Journal of Dermatology” Calretinin identifies the companion cell layer in human hair follicles.
54 citations
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September 1999 in “PubMed” K15 staining helps distinguish basal cell carcinoma from trichoepithelioma.
133 citations
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March 1999 in “Journal of Cutaneous Pathology” Trichoepitheliomas and some basal cell carcinomas likely come from hair follicle stem cells.
198 citations
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March 1999 in “Journal of Investigative Dermatology”
50 citations
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July 2008 in “British Journal of Dermatology” 138 citations
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March 2007 in “Experimental cell research” Only a few hair-specific keratins are linked to inherited hair disorders.
276 citations
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January 2005 in “International review of cytology” More research is needed to understand how hair keratins work and their role in hair disorders.
199 citations
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January 2004 in “The International Journal of Developmental Biology” Hair follicle growth and development are controlled by specific genes and molecular signals.
29 citations
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April 2003 in “Experimental dermatology” Human hair follicles grown in vitro maintain normal keratin patterns and structure.
175 citations
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January 1995 in “Birkhäuser Basel eBooks” Human hair growth and structure are influenced by keratin proteins, genes, melanin, and lipids.
2 citations
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March 1994 in “Oncology Reports” Keratoacanthomas and squamous cell carcinomas have similar keratin patterns, making them hard to tell apart.
