Keratoacanthoma and Other Types of Squamous Cell Carcinoma with Crateriform Architecture: Classification and Identification
February 2013
in “
The Journal of Dermatology
”
Studysummary This study seeks to clarify the terminology and classification of keratoacanthoma and similar squamous cell carcinoma lesions with central keratin-filled craters to aid in accurate differential diagnosis.
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The study aimed to clarify the terminology and classification of keratoacanthoma (KA) and other squamous cell carcinoma (SCC) types with crateriform architecture by evaluating 41 nodular SCC lesions. These lesions were categorized into six types: KA (well-developed stage), KA-like SCC, KA with malignant transformation, infundibular SCC (crateriform), crateriform SCC from actinic keratosis, and crateriform Bowen's disease. The study suggested that KA, KA-like SCC, KA with malignant transformation, and infundibular SCC are related to hair follicles, while crateriform SCC from actinic keratosis and crateriform Bowen's disease are not. The findings aimed to assist physicians in making accurate differential diagnoses and to standardize the terminology for KA and related neoplasms.
