Immunohistochemical Expression of Keratin Proteins in Keratoacanthomas of the Skin

    March 1994 in “ Oncology Reports ”
    Yohei Fujita, Reiki Nishimura, Masayuki Shintaku, Airo Tsubura
    TLDR Keratoacanthomas and squamous cell carcinomas have similar keratin patterns, making them hard to tell apart.
    The study examined keratin expression in eight cases of keratoacanthoma using immunohistochemical methods and compared it with normal skin and six cases of squamous cell carcinoma. The findings indicated that keratin expression in keratoacanthomas resembled that in the upper part of the outer root sheath cells of hair follicles, suggesting a possible origin from these cells. However, similar keratin expression patterns were observed in squamous cell carcinomas, making it difficult to distinguish between the two conditions based solely on keratin reactivity.
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