TLDR Keratoacanthomas and squamous cell carcinomas have similar keratin patterns, making them hard to tell apart.
The study examined keratin expression in eight cases of keratoacanthoma using immunohistochemical methods and compared it with normal skin and six cases of squamous cell carcinoma. The findings indicated that keratin expression in keratoacanthomas resembled that in the upper part of the outer root sheath cells of hair follicles, suggesting a possible origin from these cells. However, similar keratin expression patterns were observed in squamous cell carcinomas, making it difficult to distinguish between the two conditions based solely on keratin reactivity.
138 citations
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March 2007 in “Experimental cell research” Only a few hair-specific keratins are linked to inherited hair disorders.
276 citations
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January 2005 in “International review of cytology” More research is needed to understand how hair keratins work and their role in hair disorders.
199 citations
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January 2004 in “The International Journal of Developmental Biology” Hair follicle growth and development are controlled by specific genes and molecular signals.
29 citations
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April 2003 in “Experimental dermatology” Human hair follicles grown in vitro maintain normal keratin patterns and structure.
10 citations
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October 2000 in “PubMed” E6/E7 oncogenes in hair follicles cause continuous hair growth by skipping the resting phase.
2 citations
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March 1994 in “Oncology Reports” Keratoacanthomas and squamous cell carcinomas have similar keratin patterns, making them hard to tell apart.
94 citations
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February 1994 in “The journal of investigative dermatology/Journal of investigative dermatology” EGF makes hair follicles grow longer but stops hair production.
135 citations
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November 1987 in “Differentiation” Outer root sheath cells consistently express certain keratins influenced by their environment.
