Keratins of the Human Hair Follicle

The document reviewed the genomic organization and expression characteristics of human hair keratin genes, highlighting their role in hair follicle biology and hereditary disorders. It noted that research on human hair keratins lagged behind studies in other species. The review discussed the complex regulatory mechanisms of hair keratin expression and the differentiation of hair follicle compartments. It also addressed keratin-related pathologies, such as epidermolysis bullosa simplex and pachyonychia congenita, which affect the outer root sheath and nail beds, respectively. The study emphasized the need for further research to understand the molecular mechanisms governing hair follicle differentiation and keratin expression.