Characterization of a First Domain of Human High Glycine-Tyrosine and High Sulfur Keratin-Associated Protein Genes on Chromosome 21q22.1

Researchers identified a domain of high glycine-tyrosine and high sulfur keratin-associated protein (KAP) genes on human chromosome 21q22.1, spanning approximately 535 kb and containing 17 high glycine-tyrosine and 7 high sulfur KAP genes, along with 9 pseudogenes. These genes were categorized into seven high glycine-tyrosine gene families and four high sulfur gene families. The study suggested that this domain represents the complete set of high glycine-tyrosine KAP genes in the human genome. Expression studies showed varying levels of expression for 11 high glycine-tyrosine and 6 high sulfur KAP genes in the hair-forming regions.