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GlossaryKeratin Associated Protein Genes (KAP genes)

encode proteins that strengthen and structure hair

Keratin Associated Protein (KAP) genes encode for a group of proteins that are crucial in the formation and structure of hair. These proteins bind to keratin, the primary structural component of hair, to provide strength and resilience. Understanding KAP genes is important for studying hair growth, texture, and disorders like alopecia.

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research Characterization of a First Domain of Human High Glycine-Tyrosine and High Sulfur Keratin-Associated Protein Genes on Chromosome 21q22.1

100 citations, December 2002 in “Journal of biological chemistry/The Journal of biological chemistry”

Researchers mapped and categorized specific keratin-associated protein genes on human chromosome 21q22.1.

research Human KAP Genes: Only Half of It? Extensive Size Polymorphisms in Hair Keratin-Associated Protein Genes

53 citations, June 2005 in “The journal of investigative dermatology/Journal of investigative dermatology”

KAP genes show significant genetic variability, but its impact on hair traits is unclear.

research Pmg-1 and Pmg-2 Constitute a Novel Family of KAP Genes Differentially Expressed During Skin and Mammary Gland Development

22 citations, August 1999 in “Mechanisms of Development”

Pmg-1 and Pmg-2 are new genes important for skin and mammary gland development.

Hair Keratin Associated Proteins: Characterization of a Second High Sulfur KAP Gene Domain on Human Chromosome 21 in Fond Memory of Dr. Peter Steinert

research Hair Keratin Associated Proteins: Characterization of a Second High Sulfur KAP Gene Domain on Human Chromosome 21 in Fond Memory of Dr. Peter Steinert

62 citations, January 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

A second domain of high sulfur KAP genes on chromosome 21q23 is crucial for hair structure.

research Comparative Genomics of the Keratin-Associated Protein Gene Clusters in Human, Chimpanzee, and Baboon

8 citations, March 2004 in “Mammalian genome”

KAP genes are crucial for hair development and show both shared and unique traits in humans, chimpanzees, and baboons.

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community Quit vaping/smoking = 80% less loss

in Research/Science 235 upvotes 8 months ago

Quitting vaping significantly reduced hair loss for a user who was a heavy vaper and also taking finasteride. Some participants suggest nicotine's vasoconstrictive properties may worsen hair loss, while others share personal anecdotes of hair improvement after quitting smoking or vaping.

community (M24) ~5 years progress on Fin & Min. AMA

in Progress Pictures 1699 upvotes 1 year ago

The user "LandB4TimeIn3D" shared their hair loss progress using finasteride (Fin) and minoxidil (Min). They experienced shedding for the first few years but saw significant regrowth after about 2-3 years. They also mentioned using topical liquid minoxidil twice a day.

community This serum outperformed Minoxidil in a recent study. Please debunk

23 upvotes 5 years ago

A topical solution called "Multi-Peptide Serum for Hair Density" by The Ordinary Company, which contains several ingredients that are used in alternatives to Minoxidil and was found to have better results than 5% Minoxidil in a study. People who have tried it shared their experiences with the serum as well.