Comparative Genomics of the Keratin-Associated Protein Gene Clusters in Human, Chimpanzee, and Baboon

    March 2004 in “ Mammalian genome ”
    Kazunori Shibuya, Jun Kudoh, Izumi Obayashi, Atsushi Shimizu, Takashi Sasaki, Shinsei Minoshima, Nobuyoshi Shimizu
    TLDR KAP genes are crucial for hair development and show both shared and unique traits in humans, chimpanzees, and baboons.
    The document compared the keratin-associated protein (KAP) gene clusters in humans, chimpanzees, and baboons, highlighting structural and functional similarities and differences. It provided insights into the evolutionary aspects of KAP genes, crucial for hair and follicle development, suggesting conserved elements across species and specific adaptations contributing to unique hair characteristics. The study underscored the importance of KAP genes in hair biology and their potential role in understanding hair growth and disorders. Additionally, it discussed the regulation of keratin gene expression in hair follicle differentiation, chromosomal localization of human hair keratin genes, and the impact of Hoxc13 overexpression on hair keratin gene clusters and alopecia.
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