Comparative Genomics of the Keratin-Associated Protein Gene Clusters in Human, Chimpanzee, and Baboon

March 2004 in “ Mammalian genome ”

Kazunori Shibuya, Jun Kudoh, Izumi Obayashi, Atsushi Shimizu, Takashi Sasaki, Shinsei Minoshima, Nobuyoshi Shimizu

keratin-associated protein KAP genes hair follicle development hair biology hair growth hair disorders keratin gene expression hair follicle differentiation chromosomal localization hair keratin genes Hoxc13 overexpression alopecia keratin hair loss

Studysummary KAP genes are crucial for hair development and show both shared and unique traits in humans, chimpanzees, and baboons.

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research A Cluster of 21 Keratin-Associated Protein Genes Within Introns of Another Gene on Human Chromosome 21q22.3

34 citations , January 2004 in “Genomics”

In this study, researchers identified a cluster of hair-specific keratin-associated protein genes within the 21q22.3 region, revealing a novel transcription mechanism involving TSPEAR/C21orf29 that may bypass typical transcriptional termination sites.

research Characterization of a First Domain of Human High Glycine-Tyrosine and High Sulfur Keratin-Associated Protein Genes on Chromosome 21q22.1

100 citations , December 2002 in “Journal of biological chemistry/The Journal of biological chemistry”

This study identified a domain on human chromosome 21q22.1 containing various high glycine-tyrosine and high sulfur keratin-associated protein genes, revealing their diverse expression in hair-forming cells.

research Cryo-Electron Microscopy of Trichocyte (Hard Alpha-Keratin) Intermediate Filaments Reveals a Low-Density Core

48 citations , January 2002 in “Journal of Structural Biology”

This study reports that trichocyte intermediate filaments from rat vibrissae and human hair follicles may contain a hollow region at their core, suggesting unique structural properties.

Characterization of a Cluster of Human High/Ultrahigh Sulfur Keratin-Associated Protein Genes Embedded in the Type I Keratin Gene Domain on Chromosome 17q12-21

research Characterization of a Cluster of Human High/Ultrahigh Sulfur Keratin-Associated Protein Genes Embedded in the Type I Keratin Gene Domain on Chromosome 17q12-21

98 citations , June 2001 in “Journal of biological chemistry/The Journal of biological chemistry”

This study identified a cluster of genes on chromosome 17 related to hair keratin-associated proteins, including 37 genes forming seven multigene families, localized in the hair shaft's upper cortex.

research Overexpression of Hoxc13 in Differentiating Keratinocytes Results in Downregulation of a Novel Hair Keratin Gene Cluster and Alopecia

114 citations , May 2001 in “Development”

This study found that overexpressing the Hoxc13 gene in mice causes hair loss and a skin condition similar to ichthyosis, identifying several gene targets that may regulate hair growth.

research Pmg-1 and Pmg-2 Constitute a Novel Family of KAP Genes Differentially Expressed During Skin and Mammary Gland Development

22 citations , August 1999 in “Mechanisms of Development”

This study identified two novel genes, pmg-1 and pmg-2, expressed in various skin and gland tissues and potentially involved in the differentiation of epithelial cells in epidermal appendages.

research Isolation and Characterization of a Putative Keratin-Associated Protein Gene Expressed in Embryonic Skin of Mice

22 citations , July 1998 in “Journal of Investigative Dermatology”

This study identified and characterized a gene called 4C32, which is expressed in the periderm of embryonic mouse skin and has a structure similar to keratin-associated proteins.

research Sequence Data and Chromosomal Localization of Human Type I and Type II Hair Keratin Genes

52 citations , October 1995 in “Experimental Cell Research”

Human hair keratin genes hHa2 and hHb1 are located on chromosomes 17 and 12.

research Regulation of Keratin Gene Expression in Hair Follicle Differentiation

98 citations , December 1991 in “Annals of the New York Academy of Sciences”

This study found that conserved DNA motifs and expression patterns in keratin genes suggest functional regulatory similarities in hair follicle differentiation across different mammalian species.

research An Ultrahigh-Sulphur Keratin Gene of the Human Hair Cuticle Is Located at 11q13 and Cross-Hybridizes with Sequences at 11p15

15 citations , January 1991 in “Mammalian Genome”

research Structure and Expression of Genes for a Class of Cysteine-Rich Proteins of the Cuticle Layers of Differentiating Wool and Hair Follicles

67 citations , December 1990 in “The journal of cell biology/The Journal of cell biology”

This study identified two evolutionarily conserved ultra-high-sulfur keratin proteins in human and sheep hair follicles, which are specifically expressed in the hair cuticle during the late stages of fiber development.

research A Group of Type I Keratin Genes on Human Chromosome 17: Characterization and Expression

141 citations , February 1988 in “Molecular and Cellular Biology”

This study found that despite strong homology between two K16 genes, only one encoded a functional protein that assembled into keratin filaments in epithelial cells, possibly due to promoter strength differences.