Structure and Expression of Genes for a Class of Cysteine-Rich Proteins of the Cuticle Layers of Differentiating Wool and Hair Follicles

    December 1990 in “ ˜The œjournal of cell biology/˜The œJournal of cell biology ”
    Philip J. MacKinnon, Barry C. Powell, George E. Rogers
    TLDR Researchers found genes for cysteine-rich proteins that form the protective layer of hair in humans and sheep.
    The study characterized two evolutionarily conserved genes encoding ultra-high-sulfur (UHS) keratin proteins, one from human hair follicles and one from sheep wool follicles. These proteins, each 16 kD and containing over 50 cysteine residues, were identified as being highly cysteine-rich (31-36 mol%) and composed mainly of cysteine-rich and glycine-rich repeats. The genes were expressed specifically in the hair cuticle at a late stage of follicle development, as shown by tissue in situ hybridization. Genomic analysis revealed that these UHS keratin proteins are encoded by related multigene families in both human and sheep genomes.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 15 results

      community Fighting Hair loss AND Grey Hair

      in Treatment  18 upvotes 2 years ago
      The user is treating hair loss with topical Minoxidil, Finasteride, RU58841, microneedling, and Ketoconazole. For grey hair, they use L-Cysteine, L-Methionine, and PABA, and have noticed some re-pigmentation.

      community Can amino acids help with AGA

      in Chat  3 upvotes 8 months ago
      Amino acids like lysine, methionine, and cysteine may help with androgenetic alopecia when taken in high doses along with a DHT blocker. Users discuss combining these with treatments like Minoxidil, finasteride, and RU58841.

      community Dutasteride 0.5 mg - Oral Minoxidil 2.5 mg / First month

      in Progress Pictures  9 upvotes 1 year ago
      A 24-year-old male with androgenetic alopecia is using a treatment of Dutasteride 0.5 mg, oral Minoxidil 2.5 mg, L-cysteine, and a Ketoconazole/Caffeine/CBD shampoo. He's considering using a dermaroller to improve results, taking biotin and iron vitamins, and quitting nicotine due to its potential link to hair loss.

      community anything to add to my regime?

      in Advice 4 years ago
      The conversation is about a hair loss treatment regimen that includes finasteride, dutasteride, oral minoxidil, Dermapen, quercetin, N-acetyl L-cysteine, biotin, millet seed extract, MSM, OPC, green tea extract, high-dose vitamins B1-B12, boron, and silica. The user is seeking advice on additional treatments.

    Related Research

    2 / 2 results