Structure and Expression of Genes for a Class of Cysteine-Rich Proteins of the Cuticle Layers of Differentiating Wool and Hair Follicles

    December 1990 in “ ˜The œjournal of cell biology/˜The œJournal of cell biology ”
    Philip J. MacKinnon, Barry C. Powell, George E. Rogers
    TLDR Researchers found genes for cysteine-rich proteins that form the protective layer of hair in humans and sheep.
    The study characterized two evolutionarily conserved genes encoding ultra-high-sulfur (UHS) keratin proteins, one from human hair follicles and one from sheep wool follicles. These proteins, each 16 kD and containing over 50 cysteine residues, were identified as being highly cysteine-rich (31-36 mol%) and composed mainly of cysteine-rich and glycine-rich repeats. The genes were expressed specifically in the hair cuticle at a late stage of follicle development, as shown by tissue in situ hybridization. Genomic analysis revealed that these UHS keratin proteins are encoded by related multigene families in both human and sheep genomes.
    Discuss this study in the Community →

    Research cited in this study

    3 / 3 results

    Related Community Posts Join

    6 / 35 results

      community Nothing's working, I feel depressed, also hopeless for the first time

      in Update  103 upvotes 3 years ago
      A user's experience with hair loss treatments, including Finasteride, Minoxidil, Nizoral Shampoo, Rosemary Oil, Vitamin D, Biotin, Vitamin C, Zinc and Dermarolling, that have not been successful over the past 14 months. Other users gave advice on how to cope with the issue, such as exercising, changing mindset, and shaving their head.

      community Fighting Hair loss AND Grey Hair

      in Treatment  20 upvotes 3 years ago
      The user is treating hair loss with topical Minoxidil, Finasteride, RU58841, microneedling, and Ketoconazole. For grey hair, they use L-Cysteine, L-Methionine, and PABA, and have noticed some re-pigmentation.

      community Any opinions on my progression

      in Progress Pictures  6 upvotes 1 year ago
      The user experienced hair loss starting at 19 and tried treatments like finasteride and minoxidil inconsistently. They later used dutasteride, PRP, and various hair loss lotions and supplements, but faced side effects and are unsure about continuing treatment.

      community Best science-backed supplements for androgenetic alopecia? Looking for real evidence

      in Research/Science  2 upvotes 1 month ago
      The conversation discusses treatments for androgenetic alopecia, focusing on evidence-based supplements to complement finasteride. Suggestions include oral minoxidil, saw palmetto, pumpkin seed oil, tocotrienols, and various other supplements, while emphasizing the importance of scientific backing and cautioning against saw palmetto if already using finasteride.

    Related Research

    8 / 8 results