The Disruption of Sox21-Mediated Hair Shaft Cuticle Differentiation Causes Cyclic Alopecia in Mice

    May 2009 in “ Proceedings of the National Academy of Sciences ”
    Makoto Kiso, Shigekazu Tanaka, Rie Saba … Yumiko Saga
    Studysummary This study found that disrupting the Sox21 gene in mice led to progressive hair loss and regrowth, identifying Sox21 as a key regulator of hair shaft cuticle differentiation.
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    Research cited in this study 12

    1. Complex Hair Cycle Domain Patterns and Regenerative Hair Waves in Living Rodents Journal of Investigative Dermatology · 2007
    2. K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), And K28 (K25irs4) Represent The Type I Inner Root Sheath Keratins Of The Human Hair Follicle Journal of Investigative Dermatology · 2006
    3. Evidence That the Satin Hair Mutant Gene Foxq1 Is Among Multiple and Functionally Diverse Regulatory Targets for Hoxc13 During Hair Follicle Differentiation Journal of biological chemistry/˜The œJournal of biological chemistry · 2006
    4. Human Hair Keratin-Associated Proteins International review of cytology · 2006
    5. Hair Keratins And Hair Follicle-Specific Epithelial Keratins Methods in cell biology · 2004
    6. Hair Follicle Differentiation And Regulation The International Journal of Developmental Biology · 2004
    7. Cyclic Alopecia in Msx2 Mutants: Defects in Hair Cycling and Hair Shaft Differentiation Development · 2002
    8. Expression of ΔNLef1 in Mouse Epidermis Results in Differentiation of Hair Follicles into Squamous Epidermal Cysts and Formation of Skin Tumors Development · 2002
    9. The Catalog of Human Hair Keratins Journal of Biological Chemistry · 2001
    10. Overexpression of Hoxc13 in Differentiating Keratinocytes Results in Downregulation of a Novel Hair Keratin Gene Cluster and Alopecia Development · 2001
    11. Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells Cell · 2001
    12. The Catalog of Human Hair Keratins Journal of biological chemistry/˜The œJournal of biological chemistry · 1999

    Related research 6

    1. The Disruption of Sox21-Mediated Hair Shaft Cuticle Differentiation Causes Cyclic Alopecia in Mice Proceedings of the National Academy of Sciences · 2009
    2. Hair Keratin Pattern in Human Hair Follicles Grown In Vitro Experimental dermatology · 2003
    3. A Novel Epithelial Keratin, hK6irs1, Is Expressed Differentially in All Layers of the Inner Root Sheath, Including Specialized Huxley Cells of the Human Hair Follicle Journal of Investigative Dermatology · 2002
    4. Localization of Cathepsins B, D, L, LAMP-1 and μ-Calpain in Developing Hair Follicles ACTA HISTOCHEMICA ET CYTOCHEMICA · 2001
    5. A New Look Into an Old Problem: Keratins as Tools to Investigate Determination, Morphogenesis, and Differentiation in Skin Genes & Development · 1989
    6. Specific Keratins And Their Associated Proteins As Markers For Hair Follicle Differentiation 1988