The Disruption of Sox21-Mediated Hair Shaft Cuticle Differentiation Causes Cyclic Alopecia in Mice

May 2009 in “ Proceedings of the National Academy of Sciences ”

Makoto Kiso, Shigekazu Tanaka, Rie Saba, Satoru Matsuda, Atsushi Shimizu, Manabu Ohyama, Hirotaka James Okano, Toshihiko Shiroishi, Hideyuki Okano, Yumiko Saga

Sox21 hair shaft cuticle cyclic alopecia keratin keratin-associated protein catagen stage hair follicle integrity

Studysummary This study found that disrupting the Sox21 gene in mice led to progressive hair loss and regrowth, identifying Sox21 as a key regulator of hair shaft cuticle differentiation.

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