A Novel Epithelial Keratin, hK6irs1, Is Expressed Differentially in All Layers of the Inner Root Sheath, Including Specialized Huxley Cells of the Human Hair Follicle

    May 2002 in “ Journal of Investigative Dermatology ”
    Lutz Langbein, Silke Praetzel, Michael A. Rogers … Jürgen Schweizer
    Studysummary This study characterized a new human keratin, hK6irs1, specifically found in the inner root sheath of hair follicles, which suggests its role in the structural integrity and guidance of growing hair shafts.
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    Research cited in this study 25

    1. Keratinocyte Differentiation in Psoriatic Scalp: Morphology and Expression of Epithelial Keratins British Journal of Dermatology · 2006
    2. Is Loose Anagen Hair Syndrome a Keratin Disorder? Archives of Dermatology · 2002
    3. The Catalog of Human Hair Keratins Journal of Biological Chemistry · 2001
    4. Pattern of Expression of c-Myc, Max, and Bin1 in Human Anagen Hair Follicles British Journal of Dermatology · 2001
    5. Contrasting Localization of c-Myc with Other Myc Superfamily Transcription Factors in the Human Hair Follicle and During the Hair Growth Cycle ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2001
    6. A Novel Type II Cytokeratin, mK6irs, Is Expressed in the Huxley and Henle Layers of the Mouse Inner Root Sheath Journal of Investigative Dermatology · 2001
    7. A Unique Type I Keratin Intermediate Filament Gene Family Is Abundantly Expressed in the Inner Root Sheaths of Sheep and Human Hair Follicles Journal of Investigative Dermatology · 2001
    8. Characterization of a 300 Kbp Region of Human DNA Containing the Type II Hair Keratin Gene Domain Journal of Investigative Dermatology · 2000
    9. The Catalog of Human Hair Keratins Journal of biological chemistry/˜The œJournal of biological chemistry · 1999
    10. A Novel Human Type II Cytokeratin, K6hf, Specifically Expressed in the Companion Layer of the Hair Follicle ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1998
    11. Onset of Keratin 17 Expression Coincides with the Definition of Major Epithelial Lineages During Skin Development The Journal of Cell Biology · 1998
    12. Keratin 17 Gene Expression During the Murine Hair Cycle Journal of Investigative Dermatology · 1997
    13. Sequences and Differential Expression of Three Novel Human Type-II Hair Keratins Differentiation · 1997
    14. Hair Follicle Companion Layer: Reacquainting an Old Friend ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1995
    15. A Novel Human Type I Hair Keratin Gene: Evidence For Two Keratin HHa3 Isoforms Molecular Biology Reports · 1995
    16. Structural Features and Sites of Expression of a New Murine 65 kD and 48 kD Hair-Related Keratin Pair, Associated with a Special Type of Parakeratotic Epithelial Differentiation Differentiation · 1992
    17. Keratins 1 and 10 as Regular Constituents of Inner Root Sheath and Cuticle Cells in the Human Hair Follicle PubMed · 1990
    18. Expression of Keratin K14 in the Epidermis and Hair Follicle: Insights Into Complex Programs of Differentiation The Journal of Cell Biology · 1989
    19. A New Look Into an Old Problem: Keratins as Tools to Investigate Determination, Morphogenesis, and Differentiation in Skin Genes & Development · 1989
    20. Patterns of Expression of Trichocytic and Epithelial Cytokeratins in Mammalian Tissues II: Concomitant and Mutually Exclusive Synthesis of Trichocytic and Epithelial Cytokeratins in Diverse Human and Bovine Tissues (Hair Follicle, Nail Bed and Matrix, Lingual Papilla, Thymic Reticulum) Differentiation · 1988
    21. Patterns of Expression of Trichocytic and Epithelial Cytokeratins in Mammalian Tissues: Human and Bovine Hair Follicles Differentiation · 1988
    22. Keratins of the Human Hair Follicle: Hyperproliferative Keratins Consistently Expressed in Outer Root Sheath Cells In Vivo and In Vitro Differentiation · 1987
    23. Acidic and Basic Hair/Nail (Hard) Keratins: Their Colocalization in Upper Cortical and Cuticle Cells of the Human Hair Follicle and Their Relationship to Soft Keratins ˜The œjournal of cell biology/˜The œJournal of cell biology · 1986
    24. The Complement of Native Alpha-Keratin Polypeptides of Hair-Forming Cells: A Subset of Eight Polypeptides That Differ from Epithelial Cytokeratins Differentiation · 1986
    25. The Histology of Keratin Fibers 1977

    Related research 8

    1. The Disruption of Sox21-Mediated Hair Shaft Cuticle Differentiation Causes Cyclic Alopecia in Mice Proceedings of the National Academy of Sciences · 2009
    2. Functional Analysis of Keratin Components in the Mouse Hair Follicle Inner Root Sheath British Journal of Dermatology · 2004
    3. Hair Keratin Pattern in Human Hair Follicles Grown In Vitro Experimental dermatology · 2003
    4. A Novel Epithelial Keratin, hK6irs1, Is Expressed Differentially in All Layers of the Inner Root Sheath, Including Specialized Huxley Cells of the Human Hair Follicle Journal of Investigative Dermatology · 2002
    5. Localization of Cathepsins B, D, L, LAMP-1 and μ-Calpain in Developing Hair Follicles ACTA HISTOCHEMICA ET CYTOCHEMICA · 2001
    6. Specific Keratins And Their Associated Proteins As Markers For Hair Follicle Differentiation 1988
    7. Keratins of the Human Hair Follicle: Hyperproliferative Keratins Consistently Expressed in Outer Root Sheath Cells In Vivo and In Vitro Differentiation · 1987
    8. Outer Root Sheath Keratinization in Anagen and Catagen of the Mammalian Hair Follicle: A Seventh Distinct Type of Keratinization in the Hair Follicle - Trichilemmal Keratinization PubMed · 1981