Search

for
Search:

GlossaryInner Root Sheath (IRS)

layer of cells supporting and shaping the growing hair shaft

The Inner Root Sheath (IRS) is a layer of cells that surrounds and supports the growing hair shaft within the hair follicle. It plays a crucial role in shaping the hair and guiding it as it emerges from the scalp. The IRS is composed of three distinct layers: Henle's layer, Huxley's layer, and the cuticle of the inner root sheath, each contributing to the structural integrity and function of the hair follicle.

Related Terms

Learn

0 / 0 results

— no results

Research

5 / 1000+ results

research Prevalence of CYP21 Mutations and IRS1 Variant Among Women With Polycystic Ovary Syndrome and Adrenal Androgen Excess

40 citations , February 2005 in “Fertility and Sterility”

Some women with PCOS have CYP21 mutations and IRS1 variants, but these genetic factors are not major contributors to PCOS.

research Mutations in the Helix Termination Motif of Mouse Type I IRS Keratin Genes Impair the Assembly of Keratin Intermediate Filament

27 citations , November 2007 in “Genomics”

Mutations in specific keratin genes cause improper hair structure in mice due to faulty keratin protein assembly.

research Differential Expression of Type I IRS Keratin Genes in Three Breeds of Sheep

January 2012 in “Zhongguo shouyi xuebao”

Sheep breeds show different keratin gene expression in the groin, linked to hair follicle density.

research Insulin Resistance Syndrome: The Sensitive IRS

January 2018

Insulin resistance is linked to many health problems and is influenced by diet, genetics, and other factors.

research Investigation of the Hair Follicle Inner Root Sheath in Scarring and Non-Scarring Alopecia

28 citations , June 2007 in “Journal of Cutaneous Pathology”

IRS premature desquamation is not unique to CCCA and occurs in various scarring alopecias.

View more "irs" in research →

Community Join

5 / 10 results

community Any news on potential hair loss treatments?

in Research/Science 11 upvotes 1 year ago

The conversation is about seeking updates on new hair loss treatments, specifically mentioning scube3 and GT20029, with one person mentioning HMI_115 as showing promising results.

community Doing sulforaphane since 2 weeks got new babyhairs

in Product 10 upvotes 4 years ago

The user noticed new baby hairs after using sulforaphane but is still experiencing shedding. They are seeking a supplement to stop shedding, possibly grape seed extract.

community 22 Years Old, 4 Months Of Minoxidil.

in Update 670 upvotes 4 years ago

The user's experience using Minoxidil to treat hair loss, with discussion of Finasteride and RU58841 as additional treatments. Additional advice is provided on ketozolin shampoo use and microdosing finasteride.

community PP405 Won't Work Long Term: Hair Follicle Damage Due to Abuse of the ISR System

in Research/Science 59 upvotes 1 month ago

PP405 may damage hair follicles if used long-term, suggesting cycling might be necessary. Combining it with finasteride could help maintain hair growth.

community 2 years of fin, 1.5 years of minoxidil, calling it quits. Thank you.

in Shaved/buzzed 567 upvotes 2 years ago

This user has been struggling with hair loss for the past two years and attempted to treat it using finasteride and minoxidil. Despite their efforts, they have not seen any improvement in their condition, so they have decided to shave or buzz their head instead. Others gave advice on other treatments that could be tried if desired.

View more "irs" in community →