Prevalence of CYP21 Mutations and IRS1 Variant Among Women With Polycystic Ovary Syndrome and Adrenal Androgen Excess

    February 2005 in “ Fertility and Sterility ”
    Selma F. Witchel, Melissa Kahsar-Miller, Christopher E. Aston … Ricardo Azziz
    Studysummary This study suggests that although the G972R variant of the IRS1 gene might increase AA excess risk in heterozygous carriers with CYP21 mutations, both variations play a limited role in PCOS development.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 1

    1. Androgen Excess Is the Key Element in Polycystic Ovary Syndrome Fertility and Sterility · 2003

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    1. Insulin Administration Alters Gonadal Steroid Metabolism Independent of Changes in Gonadotropin Secretion in Insulin-Resistant Women with Polycystic Ovary Syndrome Journal of Clinical Investigation · 1989