Association of Gly972Arg Variant of Insulin Receptor Substrate-1 and Gly1057Asp Variant of Insulin Receptor Substrate-2 with Polycystic Ovary Syndrome in the Chinese Population

In the 2014 study involving 248 PCOS patients and 92 control subjects from Taiwan, Lin et al. found that the IRS-2 Gly1057Asp variant was significantly associated with polycystic ovary syndrome (PCOS), particularly in non-obese women. Homozygous carriers of the IRS-2 Asp variant had an increased risk of PCOS, with an odds ratio of 4.08. The IRS-1 Gly972Arg variant, however, did not show a significant difference between PCOS patients and controls. Additionally, the study reported that PCOS patients were younger and had higher body weight, BMI, and levels of various hormones and glucose compared to controls. The IRS-2 Asp/Asp genotype was also linked to higher fasting insulin levels and HOMA index. The interaction of carrying both IRS-1 Gly/Arg and IRS-2 Asp/Asp genotypes further increased the risk of PCOS, with an odds ratio of 11.87. The researchers concluded that the IRS-2 Asp/Asp genotype may be a risk factor for PCOS in the studied Chinese population.