Metabolic Syndrome and Insulin Resistance Syndrome Among Infertile Women with Polycystic Ovary Syndrome: A Cross-Sectional Study from Central Vietnam

    January 2018 in “ Endocrinology and Metabolism ”
    Minh Tâm Lê, Vu Quoc Huy Nguyen, Quang Vinh Truong, Dinh Duong Le, Viet Nguyen Sa Le, Ngọc Thành Cao
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    TLDR Many infertile women with PCOS in Central Vietnam have metabolic or insulin resistance syndrome, with obesity and older age increasing the risk.
    The study conducted in Central Vietnam from June 2016 to November 2017 with 318 infertile women with PCOS found that 10.4% had Metabolic Syndrome (MS) and 27.0% had Insulin Resistance Syndrome (IRS). Older age and obesity were significant predictors for both conditions, and dyslipidemia was the strongest predictor. Elevated anti-Müllerian hormone levels were associated with an increased risk of IRS but not MS. The study highlighted the importance of considering PCOS as a metabolic disorder and recommended that screening and early intervention for MS and IRS should be included in fertility care. Despite its prospective design and being the first to describe the metabolic profile of Vietnamese women with PCOS, the study had limitations such as the lack of a non-PCOS control group, potential selection bias, and a small sample size from a single center. The study suggests that even non-obese women with PCOS should be evaluated for metabolic disturbances and that managing metabolic risk factors should be part of fertility treatment.
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