Prevalence and Clinical Predictors of Insulin Resistance in Reproductive-Aged Thai Women with Polycystic Ovary Syndrome

January 2012 in “ International Journal of Endocrinology ”

Thanyarat Wongwananuruk, Manee Rattanachaiyanont, Suchada Indhavivadhana, Pichai Leerasiri, Kitirat Techatraisak, Prasong Tanmahasamut, Surasak Angsuwathana, Chongdee Dangrat

insulin resistance polycystic ovary syndrome PCOS hyperandrogenemia acanthosis nigricans dyslipidemia IR

TLDR Insulin resistance is found in 20% of Thai women with PCOS, with age, waist size, skin changes, and abnormal blood fats increasing the risk.

The study, which included 250 Thai women with polycystic ovary syndrome (PCOS), found a 20.0% prevalence of insulin resistance (IR). Clinical predictors for IR were identified as age ≥30 years, waist circumference ≥80 cm, presence of acanthosis nigricans, and dyslipidemia, with odds ratios of 2.14, 3.53, 2.63, and 3.07, respectively. Hyperandrogenemia was not found to be an independent predictor of IR. The study suggests the importance of screening for IR in PCOS women with these risk factors, although the findings are limited by the cross-sectional design and the urbanized sample, which may not be representative of the broader population of Thai women with PCOS. The research was conducted from May 2007 to January 2009 and was funded by the Routine to Research (R2R) management fund of the Faculty of Medicine Siriraj Hospital, Mahidol University.

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Research cited in this study

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