Prevalence and Clinical Predictors of Insulin Resistance in Reproductive-Aged Thai Women with Polycystic Ovary Syndrome

January 2012 in “ International Journal of Endocrinology ”

Thanyarat Wongwananuruk, Manee Rattanachaiyanont, Suchada Indhavivadhana, Pichai Leerasiri, Kitirat Techatraisak, Prasong Tanmahasamut, Surasak Angsuwathana, Chongdee Dangrat

insulin resistance polycystic ovary syndrome PCOS hyperandrogenemia acanthosis nigricans dyslipidemia IR

TLDR Insulin resistance is found in 20% of Thai women with PCOS, with age, waist size, skin changes, and abnormal blood fats increasing the risk.

The study, which included 250 Thai women with polycystic ovary syndrome (PCOS), found a 20.0% prevalence of insulin resistance (IR). Clinical predictors for IR were identified as age ≥30 years, waist circumference ≥80 cm, presence of acanthosis nigricans, and dyslipidemia, with odds ratios of 2.14, 3.53, 2.63, and 3.07, respectively. Hyperandrogenemia was not found to be an independent predictor of IR. The study suggests the importance of screening for IR in PCOS women with these risk factors, although the findings are limited by the cross-sectional design and the urbanized sample, which may not be representative of the broader population of Thai women with PCOS. The research was conducted from May 2007 to January 2009 and was funded by the Routine to Research (R2R) management fund of the Faculty of Medicine Siriraj Hospital, Mahidol University.

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Research cited in this study

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research Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome (PCOS)

4025 citations, December 2003 in “Human Reproduction”

The 2003 consensus updated PCOS diagnosis criteria and linked PCOS to higher risks of diabetes and heart problems, recommending lifestyle changes to lower these risks.

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6 / 165 results

community Female, 30, PCOS diagnosis, MPB Norwood 2. Endo refuses to give anything other than Spironolactone. Feel like I’m at my wit’s end here.

in Female 55 upvotes 1 year ago

A 30-year-old female with PCOS and male pattern baldness is frustrated with her endocrinologist's recommendation of only Spironolactone and minoxidil, feeling that dutasteride, finasteride, and progesterone would be more effective. Other users suggest various online sources for treatments, warn against self-medicating due to potential risks, and recommend seeking a specialized endocrinologist or considering additional treatments like Inositol, Berberine, and dermaneedling.

community Why balding gets worse in every generation?

in Chat 81 upvotes 10 months ago

Balding seems to worsen with each generation, possibly due to stress, diet, and environmental factors. The user started treatments like Minoxidil and finasteride.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 8 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community [25, F] [RANT] Shedding since March 2020. This just isn’t fair.

in Female 42 upvotes 3 years ago

User "missbloombastic" has been experiencing hair loss since 2016 and tried min, fin, multivitamins, and spiro with mixed results. Another user shares their struggle with hair loss and its impact on self-esteem, while a third user suggests checking blood tests and confirming the cause of hair loss.

community What treatment helps diffuse hair thinning from insulin resistance?

in Treatment 1 upvotes 1 year ago

The individual is experiencing hair loss due to insulin resistance (IR) and is seeking advice. They are currently using a keto diet, supplements, exercise, and plan to add metformin to their regimen.

community ‘Long term use of fin/dut may be associated with health risks including fatty liver disease, insulin resistance, type 2 diabetes, dry eye disease and potential kidney disease.’

in Research/Science 22 upvotes 9 months ago

Long-term use of finasteride and dutasteride may be linked to health risks like fatty liver disease, insulin resistance, type 2 diabetes, dry eye disease, and potential kidney disease. Some users believe the risks are low and the medications are generally safe.

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Genetic Variants Associated with Hyperandrogenemia in PCOS Pathophysiology

Prevalence and Clinical Predictors of Insulin Resistance in Reproductive-Aged Thai Women with Polycystic Ovary Syndrome

Research cited in this study

research Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome (PCOS)

Related Community Posts Join

community Female, 30, PCOS diagnosis, MPB Norwood 2. Endo refuses to give anything other than Spironolactone. Feel like I’m at my wit’s end here.

community Why balding gets worse in every generation?

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

community [25, F] [RANT] Shedding since March 2020. This just isn’t fair.

community What treatment helps diffuse hair thinning from insulin resistance?

community ‘Long term use of fin/dut may be associated with health risks including fatty liver disease, insulin resistance, type 2 diabetes, dry eye disease and potential kidney disease.’

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