Insulin Resistance and Elevated Androgen Levels: A Major Cause of Polycystic Ovary Syndrome
October 2021
in “
Frontiers in Endocrinology
”
insulin resistance hyperandrogenism Polycystic Ovary Syndrome PCOS androgens type 2 diabetes obesity hypertension metabolic syndrome cardiovascular events oral contraceptives anti-androgens insulin-sensitizing medications surgical interventions male hormones birth control pills anti-male hormones insulin-sensitizers
TLDR Insulin resistance and high male hormone levels are major causes of Polycystic Ovary Syndrome.
The document "Resistance to the Insulin and Elevated Level of Androgen: A Major Cause of Polycystic Ovary Syndrome" discusses the role of insulin resistance and hyperandrogenism in the development of Polycystic Ovary Syndrome (PCOS). The study involved 45 PCOS patients, 39 of whom had a hyperinsulinemic response. Insulin resistance can lead to an overproduction of androgens, male hormones, causing PCOS, a hormonal disorder common among women of reproductive age. PCOS is associated with a higher risk of type 2 diabetes, obesity, hypertension, metabolic syndrome, and cardiovascular events. The study suggests that managing insulin resistance could be a key strategy in treating PCOS. Current treatments for PCOS include lifestyle changes, oral contraceptives, anti-androgens, insulin-sensitizing medications, and surgical interventions. Further research is needed to clarify the mutual role of insulin resistance and hyperandrogenism in PCOS development.
