Abdominal Fat Quantity and Distribution in Women with Polycystic Ovary Syndrome and Its Relation to Insulin Resistance

    April 2007 in “ The Journal of Clinical Endocrinology and Metabolism ”
    Enrico Carmina, Salvo Bucchieri, Antonella Esposito, Antonio Del Puente, Pasquale Mansueto, Francesco Orio, Gaetana Di Fede, G. B. Rini
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    TLDR Women with PCOS often have more belly fat and higher insulin levels, but belly fat isn't the only cause of their insulin resistance.
    The study from 2007 with 222 participants investigated the relationship between abdominal fat and insulin resistance in 110 women with Polycystic Ovary Syndrome (PCOS) and 112 weight-matched controls. It found that PCOS patients had a higher quantity of central abdominal fat compared to controls, particularly in overweight and normoweight individuals, and this was associated with higher insulin levels and reduced insulin sensitivity. However, the study concluded that increased abdominal fat is not the sole determinant of insulin resistance in PCOS, as other factors may also play a role. The findings suggest that while abdominal obesity is common in PCOS, it is not the only factor contributing to the metabolic disturbances observed in the condition.
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