Obesity and Polycystic Ovary Syndrome: Implications for Pathogenesis and Novel Management Strategies

    January 2019 in “ Clinical medicine insights ”
    Thomas M. Barber, Petra Hanson, Martin O. Weickert, Stephen Franks
    Image of study
    TLDR Obesity worsens PCOS symptoms, and PCOS may lead to more weight gain; managing both requires a holistic approach that includes mental health.
    The document from 2019 reviews the relationship between obesity and Polycystic Ovary Syndrome (PCOS), emphasizing the bidirectional nature of their impact on each other. It explains how obesity exacerbates PCOS through mechanisms like insulin resistance and hyperinsulinaemia, and how PCOS may contribute to further weight gain. The review also discusses the increased risk of obstructive sleep apnoea (OSA) in women with PCOS and the effectiveness of treatments like CPAP therapy and bariatric surgery. A large study (n=178) is mentioned, showing a link between PCOS and increased 5-alpha reductase activity, and a meta-analysis of over 3,400 subjects indicates lower adiponectin levels in women with PCOS. Genetic factors, such as FTO gene variants, are implicated in PCOS development. The document suggests that emotional barriers can hinder physical activity in women with PCOS and that long-term weight management strategies, including mindfulness and moderate exercise, are important. It calls for a holistic approach to treatment, with sensitivity to mental and emotional health issues.
    Discuss this study in the Community →

    Research cited in this study

    10 / 10 results

    Related Community Posts Join

    6 / 12 results

      community Female, 30, PCOS diagnosis, MPB Norwood 2. Endo refuses to give anything other than Spironolactone. Feel like I’m at my wit’s end here.

      in Female  56 upvotes 1 year ago
      A 30-year-old female with PCOS and male pattern baldness is frustrated with her endocrinologist's recommendation of only Spironolactone and minoxidil, feeling that dutasteride, finasteride, and progesterone would be more effective. Other users suggest various online sources for treatments, warn against self-medicating due to potential risks, and recommend seeking a specialized endocrinologist or considering additional treatments like Inositol, Berberine, and dermaneedling.

      community How does hair loss and recovery work?

      in Chat  12 upvotes 2 months ago
      Hair loss varies due to genetic sensitivity to DHT and other factors. Treatments discussed include finasteride, minoxidil, RU58841, and microneedling.

      community C’est terrible - at my wits end

      in Female  443 upvotes 1 year ago
      A 29-year-old woman is experiencing gradual hair thinning since age 15, suspects Androgenic Alopecia, and has tried 5% minoxidil with little success. She has purchased various hair loss treatments including minoxidil, dutasteride, finasteride, and spironolactone, but is cautious about starting them due to potential interactions with her ADHD medication.

      community Why balding gets worse in every generation?

      in Chat  81 upvotes 5 months ago
      Balding seems to worsen with each generation, possibly due to stress, diet, and environmental factors. The user started treatments like Minoxidil and finasteride.

    Similar Research

    5 / 1000+ results