Polycystic Ovary Syndrome: Insight Into Pathogenesis and a Common Association With Insulin Resistance

The document from December 2015 examines the connection between polycystic ovary syndrome (PCOS) and insulin resistance, noting that 50-90% of women with PCOS have insulin resistance, which exacerbates the condition. Insulin resistance in PCOS is not solely due to excess visceral fat, and weight loss is highlighted as the most effective treatment, with even a 5% reduction in weight leading to significant improvements in symptoms. The document suggests that improving insulin sensitivity through weight loss or medication can help manage PCOS features. It also points out the need for novel weight-loss therapies, with brown adipose tissue (BAT) identified as a potential target. The conclusion emphasizes the importance of developing treatments that promote weight loss and improve insulin sensitivity to enhance PCOS outcomes and the necessity for healthcare professionals to be knowledgeable about PCOS due to its commonality and associated health risks.